The genomic revolution : unveiling the unity of life /

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作   者:Michael Yudell and Robert DeSalle, editors.

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ISBN:9780309074360

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简介

From the discoveries of Watson and Crick to the appearance of Dolly the Sheep, the past fifty years have ushered in a revolution of knowledge in how organisms develop, function, and procreate. Scientists are now engaged in an epic task that will vastly expand our knowledge: the sequencing of the human genome. Indeed, preliminary results of the Human Genome Project have revealed the remarkable unity of life, from one-celled creatures to human beings. Consider briefly the scope of such a discovery. How different are we from one another? Does race have a scientific meaning? Is there such a thing as a disease gene? What are the potential risks of genetically modified food? The Human Genome Project will inevitably lead to landmark changes in medicine, agriculture, and the study of evolution--and will ultimately define the course of human history. The Genomic Revolution: Unveiling the Unity of Life takes readers on a fascinating journey through genomics--from the basic presentation of ideas about heredity through the essential principles of molecular biology, including an exploration of the ethical implications of the genome project for individuals and society. Some of the world's leading experts in genomics--Harold Varmus, Leroy Hood, Mary Jeanne Kreek, Daniel Kevles, and Craig Venter, to name just a few--contribute their assessment of the state of current scientific research. Written for anyone wondering why we are the way we are, The Genomic Revolution is an extraordinary discussion of the building blocks of life. this timely and important collection spans the science, the promise, and the potential pitfalls of a field moving so quickly that its achievements may alternately delight and trouble us, but almost always surprise us. - Dust jacket.

目录






Part I
Genome Science and the New Frontier
Introduction 15
Nicholas Wade



What Does Knowing About Genomes Mean for Science
and Society? 2C
Harold Varmus
Sequencing the Human Genome: Elucidating Our Genetic
Blueprint 35
Eric Green
Whole-Genome Shotgun Sequencing 48
J. Craig Venter
After the Genome: Where Should We Go? 64
Leroy Hood
Part II
Applications of Genomics to Medicine and Agriculture
Introduction 77
Robert Bazell
Genomics: Rapid Road from Gene to Patient 79
William Haseltine
The Origins of Cancer and the Human Genome 87
Arnold . Levine
Gene Diversity in the Endorphin System: SNPs, Chips, and
Possible Implications 97
Mary Jeanne Kreek
Genomics and Biotechnology in Agriculture 109
Barbara A. Schaal



Part III
Exploring Human Variation: Understanding Identity in the Genomic Era
Introduction 127
Rob DeSalle
Using Maternal and Paternal Genes to Unlock Human
History 131
Douglas C. Wallace
Eugenics, the Genome, and Human Rights 147
Daniel . Kevles
Redesigning the Self: The Promise and Perils of Genetic
Enhancement 155
David J. Rothman and Sheila M. Rothman
Part IV
Financial, Legal, and Ethical Issues and the New Genomics
Introduction 167
Michael Waldholz
Investing in the Biotechnology Sector 169
Kris H. Jenner
The Role of Patents in Exploiting the Genome 175
Rebecca Eisenberg
Social Side Effects of the New Human Molecular Genetic
Diagnostics 184
Troy Duster



Mapping Morality: The Rights and Wrongs of Genomics 193
Arthur L. Caplan
Summing Up: Finding Our Way Through the Revolution 199
Kathi E. Hanna
Appendixes
A Contributor Biographical Sketches 211
B Conference Schedule 229
Index 235





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