简介
电磁高热疗法治疗癌症是将射频或微波探针插入到肿瘤区域，从而达到利用电磁能杀死癌细胞的目的。与此同时，在20世纪，纳米材料也被引入到癌症的治疗中。 本书主要内容是纳米材料的电磁加热效应用于肿瘤治疗。主要讨论了金纳米颗粒在直流、261 kHz、13．56 MHz、2．45 GHz、毫米波、太赫兹和可见光情形下的电磁特性；分析了不同的频率和加热场景下的电磁波对金纳米颗粒的加热效果。第l章介绍电磁场与纳米材料用于肿瘤治疗的背景和应用；第2章重点介绍电磁加热和纳米材料的基本特性；第3章讨论的是261 kHz、13．56 MHz、2．45 GHz下的金纳米材料的加热效果；第4章讨论毫米波和太赫兹波段金纳米材料的介电性质；第5章讨论的是在直流和光波段的加热情形。
目录
Abstract
Acknowledgements
Abbreviations and Glossary
Symbols and Units
Chapter 1 Introduction
1.1 Overview
1.2 Physical properties
1.2.1 Surface to-volume ratio and size dependent properties
1.2.2 Quantum size effect
1.2.3 Superparamagnetism
1.2.4 Surface plasmon resonance
1.3 Applications of gold nanoparticles
1.3.1 Biosensing and bioimaging
1.3.2 Drug delivery and cancer treatment
1.4 Review of the interaction of electromagnetic waves with gold nanopartieles
1.5 The main contents of this book
1.6 Outlines of this book
References
Chapter 2 Gold Nanoparticles: Synthesis, Dielectric and Optical Properties
2.1 Overview
2.2 Preparation of gold nanoparticles
2.3 Fundamentals of dielectric properties
2.3.1 Fundamentals
2.3.2 Drude model for dielectric properties of metals
2.3.3 Dielectric model for mixed medium
2.4 Dielectric measurement methods
2.4.1 Open-ended coaxial method
2.4.2 Free-space method
2.5 Optical properties
2.6 Summary
References
Chapter 3 Study of GNPs' Heating Effect for Cancer Treatment
3.1 Overview
3.2 Dielectric measurement
3.2.1 Experimental setup
3.2.2 Measured results
3.2.3 Discussion
3.3 RF heating study
3.3.1 Microstrip waveguide exposure system
3.3.2 Power calibration and field strength measurement
3.3.3 Heating effect study
3.3.4 In vitro study
3.4 Heating effect using Kanzius exposure system
3.5 Discussions on the RF heating study
3.6 Magnetic heating effect
3.7 Microwave heating effect
3.7.1 Experiment setup
3.7.2 Experiment results
3.8 Summary
References
Chapter 4 Study of GNP's Interaction with Millimetre and THz Waves
4.1 Overview
4.2 Operating principles and experiment instrumentations
4.2.1 Quasi-optical techniques
4.2.2 THz time domain spectroscopy
4.3 Experiment results
4.3.1 Dielectric properties in the millimetre wave range
4.3.2 Dielectric properties in the THz range
……
Chapter 5 Study of Static Electric Field Induced Size-dependent Optical Properties of GNP
Chapter 6 Summary and Future Work
Appendix I--Conductivity Dependent Field Strength and Temperature Rise
Appendix II--Control Circuit
Appendix III--CIE Colour Diagram
Appendix IV--Surface Plasmon Resonance and Measurement Method
Acknowledgements
Abbreviations and Glossary
Symbols and Units
Chapter 1 Introduction
1.1 Overview
1.2 Physical properties
1.2.1 Surface to-volume ratio and size dependent properties
1.2.2 Quantum size effect
1.2.3 Superparamagnetism
1.2.4 Surface plasmon resonance
1.3 Applications of gold nanoparticles
1.3.1 Biosensing and bioimaging
1.3.2 Drug delivery and cancer treatment
1.4 Review of the interaction of electromagnetic waves with gold nanopartieles
1.5 The main contents of this book
1.6 Outlines of this book
References
Chapter 2 Gold Nanoparticles: Synthesis, Dielectric and Optical Properties
2.1 Overview
2.2 Preparation of gold nanoparticles
2.3 Fundamentals of dielectric properties
2.3.1 Fundamentals
2.3.2 Drude model for dielectric properties of metals
2.3.3 Dielectric model for mixed medium
2.4 Dielectric measurement methods
2.4.1 Open-ended coaxial method
2.4.2 Free-space method
2.5 Optical properties
2.6 Summary
References
Chapter 3 Study of GNPs' Heating Effect for Cancer Treatment
3.1 Overview
3.2 Dielectric measurement
3.2.1 Experimental setup
3.2.2 Measured results
3.2.3 Discussion
3.3 RF heating study
3.3.1 Microstrip waveguide exposure system
3.3.2 Power calibration and field strength measurement
3.3.3 Heating effect study
3.3.4 In vitro study
3.4 Heating effect using Kanzius exposure system
3.5 Discussions on the RF heating study
3.6 Magnetic heating effect
3.7 Microwave heating effect
3.7.1 Experiment setup
3.7.2 Experiment results
3.8 Summary
References
Chapter 4 Study of GNP's Interaction with Millimetre and THz Waves
4.1 Overview
4.2 Operating principles and experiment instrumentations
4.2.1 Quasi-optical techniques
4.2.2 THz time domain spectroscopy
4.3 Experiment results
4.3.1 Dielectric properties in the millimetre wave range
4.3.2 Dielectric properties in the THz range
……
Chapter 5 Study of Static Electric Field Induced Size-dependent Optical Properties of GNP
Chapter 6 Summary and Future Work
Appendix I--Conductivity Dependent Field Strength and Temperature Rise
Appendix II--Control Circuit
Appendix III--CIE Colour Diagram
Appendix IV--Surface Plasmon Resonance and Measurement Method
电磁场与纳米材料的相互作用
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