
Rudolph's pediatrics /
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ISBN:9780071497237
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Summary: Publisher Summary 1 The landmark pediatrics reference -- now extensively updated in full color and more clinically relevant than everA Doody's Core Title ESSENTIAL PURCHASE for 2011!Rudolph's Pediatricshas virtually defined the pediatric field for over a century, becoming one of the most important and well-respected pediatrics texts ever published. Renowned for its balance of clinical features and treatment of disease with underlying biological principles, this classic sourcebook has helped generations of pediatricians optimize their care of infants, children, and adolescents. The 22nd edition of Rudolph's Pediatricscontinues a long tradition of adapting its content to changes in our understanding of children's health and disease, providing an up-to-date, in-depth survey of pediatric medicine unmatched by any other text. With its algorithmic approach to pediatric systems, the book facilitates the diagnosis and treatment of both common and uncommon pediatric illnesses; and it reflects new technologies and advances in molecular medicine that continue to evolve with current thinking about normal childhood development and pediatric disease processes.NEW TO THIS EDITION: New four-color design adds depth and clarity to the book's content Over 900 full-color, high-quality images and illustrations A reorganized, reader-friendly format broken down into sections and chapters for easier navigation and referenceNew emphasis on the clinical management of the patient makes this the most practical edition to dateNew sections provide a timely overview of pediatric care fundamentals and an entirely revised discussion of health promotion and disease preventionSubstantially revised sections cover key areas of pediatric study and practice, including infectious diseases, immunology, allergy, neoplastic disorders, the cardiovascular system, urinary complications, and more Greater use of tables and lists conveniently summarize need-to-know diagnostic and therapeutic informationNew DVD of additional content featuring over 1700 figures, 1100 tables, and 30,000 references
目录
Table Of Contents:
Contributors xxvii
Preface liii
Acknowledgments lv
Section 1 Fundamentals of Pediatrics
Thomas G. DeWitt
1 Role of the Pediatrician 1(2)
Thomas G. DeWitt
Neal Halfon
2 Decision Making: Use of Evidence-Based Medicine 3(2)
Suresh Nagappan
Kenneth B. Roberts
3 Communication 5(7)
Elizabeth A. Rider
4 Interviewing Techniques 12(3)
Christopher F. Boiling
5 Systems of Practice and Office Management 15(2)
Peter Margolis
6 Core Competencies 17(2)
Theodore C. Sectish
7 Patient and Family-Centered Care 19(2)
Jeffrey M. Simmons
Stephen E. Muething
Kathleen L. Dressman
8 Disaster Preparedness 21(3)
Janet M. Berreman
Linda Rudolph
9 Law, Ethics, and Clinical Judgment 24(3)
Angela Roddey Holder
Section 2 Health Promotion and Disease Prevention
Eve R. Colson
Part 1 Health Maintenance Issues
10 Well-Child Care 27(7)
Judith S. Shaw
Judith S. Palfrey
11 Child Development 34(8)
Ilgi Ozturk Ertem
Carol Cohen Weitzman
12 Screening 42(5)
Ada M. Fenick
13 Oral Health Supervision 47(5)
Ada M. Fenick
Linda P. Nelson
14 Complementary and Alternative Medicine (CAM) 52(8)
Anju Sawni
15 Culture and Pediatric Practice 60(3)
Sakena Abedin
16 Gay and Lesbian Parents 63(3)
Cindy M. Schorzman
Melanie A. Gold
17 Environmental Pediatrics 66(6)
Ruth A. Etzel
18 Travel Medicine 72(5)
Joseph A. Zenel
Chandy C. John
Part 2 Managing Family Transition
19 Family Function and Birth of a Child 77(2)
William I. Cohen
20 Foster Care and Adoption 79(5)
Brad D. Berman
Carol Cohen Weitzman
21 Family Discord and Divorce 84(2)
Michael Jellinek
22 Supporting the Grieving Child and Family 86(3)
David J. Schonfeld
Section 3 Nutrition
Praveen S. Goday
23 Normal Nutritional Requirements 89(6)
Praveen S. Goday
24 Breast-Feeding 95(4)
Jane Morton
Ruth A. Lawrence
25 Infant Formula and Complementary Foods 99(6)
Margaret Kirby
26 Postdischarge Nutritional Management of the Premature Infant 105
Utpala G. Das
Contributors xxvii
Preface liii
Acknowledgments lv
Section 1 Fundamentals of Pediatrics
Thomas G. DeWitt
1 Role of the Pediatrician 1(2)
Thomas G. DeWitt
Neal Halfon
2 Decision Making: Use of Evidence-Based Medicine 3(2)
Suresh Nagappan
Kenneth B. Roberts
3 Communication 5(7)
Elizabeth A. Rider
4 Interviewing Techniques 12(3)
Christopher F. Boiling
5 Systems of Practice and Office Management 15(2)
Peter Margolis
6 Core Competencies 17(2)
Theodore C. Sectish
7 Patient and Family-Centered Care 19(2)
Jeffrey M. Simmons
Stephen E. Muething
Kathleen L. Dressman
8 Disaster Preparedness 21(3)
Janet M. Berreman
Linda Rudolph
9 Law, Ethics, and Clinical Judgment 24(3)
Angela Roddey Holder
Section 2 Health Promotion and Disease Prevention
Eve R. Colson
Part 1 Health Maintenance Issues
10 Well-Child Care 27(7)
Judith S. Shaw
Judith S. Palfrey
11 Child Development 34(8)
Ilgi Ozturk Ertem
Carol Cohen Weitzman
12 Screening 42(5)
Ada M. Fenick
13 Oral Health Supervision 47(5)
Ada M. Fenick
Linda P. Nelson
14 Complementary and Alternative Medicine (CAM) 52(8)
Anju Sawni
15 Culture and Pediatric Practice 60(3)
Sakena Abedin
16 Gay and Lesbian Parents 63(3)
Cindy M. Schorzman
Melanie A. Gold
17 Environmental Pediatrics 66(6)
Ruth A. Etzel
18 Travel Medicine 72(5)
Joseph A. Zenel
Chandy C. John
Part 2 Managing Family Transition
19 Family Function and Birth of a Child 77(2)
William I. Cohen
20 Foster Care and Adoption 79(5)
Brad D. Berman
Carol Cohen Weitzman
21 Family Discord and Divorce 84(2)
Michael Jellinek
22 Supporting the Grieving Child and Family 86(3)
David J. Schonfeld
Section 3 Nutrition
Praveen S. Goday
23 Normal Nutritional Requirements 89(6)
Praveen S. Goday
24 Breast-Feeding 95(4)
Jane Morton
Ruth A. Lawrence
25 Infant Formula and Complementary Foods 99(6)
Margaret Kirby
26 Postdischarge Nutritional Management of the Premature Infant 105(2)
Utpala G. Das
27 Nutritional Issues: Toddler to Adolescent 107(3)
Margaret Kirby
Praveen S. Goday
28 Assessment of Nutritional Adequacy 110(1)
Praveen S. Goday
29 Malnutrition and Refeeding 111(3)
Praveen S. Goday
30 Poor Weight Gain 114(3)
Karen A. Francolla
Praveen S. Goday
31 Approach to the Infant and Child with Feeding Difficulty 117(6)
Richard J. Noel
32 The Overweight or Obese Child 123(3)
Michelle Smith-Beckley
Brian M. Fidlin
33 Specialized Nutrition Support 126(8)
Praveen S. Goday
34 Nutritional Access Devices 134(3)
Lillian Sablan
Karen Sherry
Section 4 Abuse, Neglect, Violence
John M. Leventhal
35 Child Maltreatment: Neglect to Abuse 137(7)
John M. Leventhal
Andrea G. Asnes
36 Family and Community Violence 144(6)
Renee Boynton-Jarrett
Robert Sege
37 Child Abuse Prevention: What Pediatricians Can Do 150(5)
Wendy Gwirtzman Lane
Howard Dubowitz
Section 5 Newborn
Alan H. Jobe
James M. Greenberg
Part 1 Care of the Newborn
38 Historical Perspectives 155(1)
James M. Greenberg
39 Care of the Fetus 155(3)
Alan H. Jobe
40 Fetal Disorders 158(2)
Timothy M. Crombleholme
Foong-Yen Lim
41 Neonatal Mortality and Morbidity 160(4)
Avroy A. Fanaroff
42 Delivery Room Resuscitation 164(6)
Myra H. Wyckoff
43 Transitional Changes in the Newborn 170(4)
David P. Carlton
44 Examination of the Newborn Infant 174(10)
Joseph A. Zenel
45 Postnatal Care and Observation 184(6)
Anthony E. Burgos
Part 2 Infants at Risk
46 Multiple Births 190(1)
James M. Greenberg
47 The Small-for-Gestational-Age Infant 191(4)
William W. Hay Jr
48 Infant of a Diabetic Mother 195(4)
Heather Morein French
Rebecca A. Simmons
Part 3 Specific Neonatal Conditions
49 Approach to the Cyanotic Infant 198(3)
Robin H. Steinhorn
50 Abnormalities of the Lungs 201(10)
M. Grisel Galarza
Ilene R. S. Sosenko
51 Metabolic Abnormalities 211(10)
William W. Hay Jr
52 Brain Abnormalities and Injuries 221(5)
Seetha Shankaran
C. Michael Cotton
53 Hematologic Abnormalities and Jaundice 226(7)
Henry C. Lee
Ashima Madan
Part 4 Disorders Specifically Related to Preterm Birth
54 Respiratory Distress Syndrome 233(5)
Thomas N. Hansen
Samuel Hawgood
55 Patent Ductus Arteriosus and Ductus Venosus 238(4)
Ronald I. Clyman
56 Hemodynamics 242(4)
Nick Evans
57 Necrotizing Enterocolitis 246(3)
Barbara Warner
58 Intraventricular Hemorrhage 249(4)
Henrietta S. Bada
59 Bronchopulmonary Dysplasia 253(3)
Alan H. Jobe
60 Emergencies 256(2)
James M. Greenberg
61 Special Intensive Care 258(3)
Thomas A. Parker
62 Outcomes of Preterm and Term Infants 261(4)
Marilee C. Allen
Section 6 Principles of Adolescent Care
Charles E. Irwin Jr.
Mary-Ann Shafer
Anna-Barbara Moscicki
Part 1 Growth and Development
63 Somatic Growth and Development 265(2)
Charles E. Irwin Jr.
64 Reproductive Growth and Development in the Female Adolescent 267(2)
Melissa Slivka
Anna-Barbara Moscicki
Mary-Ann Shafer
65 Reproductive Growth and Development in the Male Adolescent 269(2)
David J. Breland
Mark L. Rubinstein
66 Psychological Development 271(1)
Elizabeth M. Ozer
Charles E. Irwin Jr.
67 The Adolescent Visit 272(5)
Charles E. Irwin Jr.
Part 2 Health Problems of Adolescents
68 Mortality 277(1)
Elizabeth M. Ozer
69 Morbidity 277(1)
Charles E. Irwin Jr.
70 Sexual Behavior 278(1)
Erica B. Monasterio
71 Substance Use and Abuse 278(4)
Stephanie N. Crewe
Arik V. Marcell
Part 3 Mental Health Disorders in the Adolescent
72 Depression, Anxiety, and Other Disorders 282(6)
Kim Peter Norman
73 Disorders of Eating 288(4)
Kim Peter Norman
Sara M. Buckelew
Andrea K. Garber
Part 4 Reproductive Health Problems
74 Breast Masses 292(2)
Jennifer C. Edman
Mary-Ann Shafer
75 Scrotal Masses 294(2)
David J. Breland
Mark L. Rubinstein
76 Menstrual Problems 296(3)
Jennifer C. Edman
Mary-Ann Shafer
77 Intrauterine and Ectopic Pregnancy 299(2)
Erica B. Monasterio
Mary-Ann Shafer
78 Contraception 301(4)
Erica B. Monasterio
Mary-Ann Shafer
Section 7 Developmental and Behavioral Pediatrics
Martin T. Stein
Part 1 General Concepts
79 Introduction to Developmental and Behavioral Pediatrics 305(1)
Martin T. Stein
80 Fundamental Concepts of Child Development 306(4)
W. Thomas Boyce
Jack P. Shonkoff
81 Brain Development and Behavior 310(3)
Charles A. Nelson III
82 Standardized Developmental Screening and Assessment Instruments 313(5)
Martin T. Stein
Part 2 Developmental Variation to Disorder
83 Crying in Infants 318(3)
Ronald G. Ban
Takeo Fujiwara
84 Hyperactivity and Inattention 321(6)
Martin T. Stein
Michael I. Reiff
85 Learning Problems 327(4)
Michael I. Reiff
Martin T. Stein
86 Language Delay 331(4)
James S. Andrews
Heidi M. Feldman
87 Difficult Behavior 335(3)
Martin T. Stein
88 Anxiety 338(4)
Denise A. Chavira
89 Repetitive Behaviors 342(4)
Adrian D. Sandler
90 Gender Identity and Sexual Behavior 346(2)
Kenneth J. Zucker
91 Developmental Delay 348(4)
Nathan J. Blum
Part 3 Major Psychopathologic Disorders
92 Autistic Spectrum Disorders 352(4)
Michael I. Reiff
93 Affective Disorders and Suicide 356(4)
Laura Prager
Steven C. Schlozman
Michael Jellinek
94 Pediatric Condition Falsification 360(1)
Herbert Schreier
95 Childhood Schizophrenia 361(2)
Fred R. Volkmar
Part 4 Psychosocial Context of Development and Behavior
96 Families in the 21st Century: An Introduction to Families 363(1)
Laurie J. Bauman
Ruth E. K. Stein
97 Nonparental Childcare 364(2)
Nerissa S. Bauer
98 Vulnerable Child Syndrome 366(2)
Yi Hui Liu
99 Adaptation to Illness 368(2)
David J. Schonfeld
Ellen C. Perrin
100 Poverty, Homelessness, and Social Disorganization 370(2)
Barry S. Zuckerman
Megan Sandel
101 Resiliency in Children and Adolescents 372(3)
Saul Levine
Section 8 The Acutely III Infant and Child
Julio Perez Fontan
George E. Lister
Part 1 Assessment of the Acutely III Infant and Child
102 Respiratory Distress and Failure 375(8)
Julio Perez Fontan
103 Decreased Perfusion and Circulatory Shock 383(8)
George E. Lister
104 Acute Neurological Dysfunction 391(6)
Susan T. Arnold
105 The Febrile Child 397(3)
M. Douglas Baker
Jeffrey R. Avner
Part 2 Stabilization and Management of the Acutely III Infant and Child
106 Monitoring of Vital Function 400(4)
George E. Lister
107 Vascular Access 404(4)
Andreas A. Theodorou
Robert A. Berg
108 Cardiopulmonary Resuscitation 408(4)
Mary Fran Hazinski
109 Life Support Systems 412(5)
Julio Perez Fontan
110 Stabilization and Transport 417(3)
Deborah Lerner
George E. Lister
Julio Perez Fontan
111 Management of Cerebral Edema and Elevated Intracranial Pressure 420(2)
Steven G. Kernie
112 Perioperative Care 422(4)
Desmond B. Henry
113 Pain Management and Sedation 426(6)
Alan Farrow-Gillespie
114 Acute Metabolic Dysfunction 432(4)
Ralph J. DeBerardinis
Part 3 Injuries and Untoward Events
115 Acute Inflammation 436(4)
Clifford W. Bogue
116 Trauma, Burns, and Bites 440(6)
Robert P. Foglia
117 Submersion Injury 446(3)
Pamela J. Okada
M. Douglas Baker
118 Foreign-Body Aspiration 449(2)
Margaret A. Kenna
119 Apparent Life-Threatening Events and SIDS 451(4)
Michael J. Corwin
120 Toxic Ingestions and Exposures 455(15)
Sing-Yi Feng
Collin S. Goto
M. Douglas Baker
121 Heat Stress 470(2)
Michael Apkon
122 Poisonous Bites and Stings 472(7)
Dee Hodge III
Carl R. Baum
Section 9 The Chronically III Infant and Child
Julia Perez Fontan
George E Lister
Part 1 The Changing Outlook of Chronic Illness in Childhood
123 Psychological and Behavioral Responses 479(5)
Patricia J. Hicks
124 The Technology-Dependent Child 484(10)
John B. Gordon
Sarah P. Brown
Jerie Beth Karkos
Lynn A. D Andrea
Part 2 Death and Dying in Childhood
125 Caring for Children Dying from Chronic Disease 494(7)
Arthur R. Ablin
126 Hospice and Palliative Care 501(9)
Julie Hauer
Barbara L. Jones
Joanne Wolfe
127 Law, Ethics, and Caring Near the End of Life 510(3)
Angela Roddey Holder
Section 10 Transplantation
Patrick J. Healey
128 Pediatric Transplantation 513(5)
Patrick J. Healey
129 Kidney Transplantation 518(3)
Jodi M. Smith
Ruth A. McDonald
130 Liver Transplantation 521(4)
Patrick J. Healey
131 Intestinal and Multivisceral Transplant 525(3)
Simon Horslen
132 Heart Transplant 528(3)
Beth D. Kaufman
133 Hematopoietic Cell Transplantation 531(10)
Ann E. Woolfrey
Paul A. Carpenter
Jean E. Sanders
Section 11 Inherited Disorders of Metabolism
Jean-Marie Saudubray
Part 1 Inborn Errors of Metabolism
134 Principles of Inborn Errors of Metabolism 541(20)
Jean-Marie Saudubray
Joe T. R. Clarke
Part 2 Disorders of Amino Acid (AA) and Organic Acid (OA) Metabolism
135 Hyperphenylalaninemias 561(2)
Bernd Christian Schwahn
136 Disorders of Tyrosine Metabolism 563(2)
Bernd Christian Schwahn
137 Disorders of Branched Chain Amino and Organic Acid Metabolism 565(4)
Stephen I. Goodman
Jean-Marie Saudubray
138 Disorders of Sulfur-Containing Amino Acid Metabolism 569(3)
Bernd Christian Schwahn
139 Disorders of Glycine, Serine, and Proline Metabolism 572(2)
Bernd Christian Schwahn
140 Disorders of Metabolism of Lysine, Hydroxylysine, and Related Compounds 574(1)
Stephen I. Goodman
141 Disorders of Metabolism of Neurotransmitter Amino Acids 574(3)
Jaak Jaeken
142 Disorders of Creatine and Ornithine Metabolism 577(2)
Sylvia Stockler-Ipsiroglu
143 Disorders of Amino Acid Transport Across Cell Membranes 579(2)
Kirsti Nanto-Salonen
Ollie Simell
144 Other Disorders of Amino Acid Metabolism 581(1)
Jean-Marie Saudubray
145 Urea Cycle and Related Disorders 582(6)
Mendel Tuchman
Uta Lichter-Konecki
Mark L. Batshaw
Part 3 Inborn Errors of Water Soluble Vitamins
146 Introduction 588(1)
Stephen I. Goodman
147 Vitamin B12 and Folic Acid 588(3)
David Watkins
David S. Rosenblatt
148 Biotin Responsive Disorders 591(1)
Stephen I. Goodman
149 Vitamin B6 and Vitamin B1 Responsive Disorders 592(2)
Jean-Marie Saudubray
Part 4 Disorders of Fatty Acid Oxidation, Ketogenesis, and Ketolysis
150 Disorders of Fatty Acid Oxidation 594(3)
Stephen I. Goodman
151 Disorders of Ketogenesis 597(1)
Stephen I. Goodman
152 Disorders of Ketolysis 598(1)
Stephen I. Goodman
153 Disorders of Leukotriene Synthesis and Fatty Aldehyde Dehydrogenase 598(1)
Stephen I. Goodman
Part 5 Carbohydrate Metabolism
154 Disorders of Glycogen Metabolism 599(8)
Priya S. Kishnani
Yuan-Tsong Chen
155 Disorders of Galactose and Fructose Metabolism and Gluconeogenesis 607(3)
Priya S. Kishnani
Yuan-Tsong Chen
156 Disorders of Pentose Phosphate Pathway 610(1)
Priya S. Kishnani
Yuan-Tsong Chen
157 Disorders of Glucose Transporters 610(4)
Rene Santer
Part 6 Disorders of Oxidative Phosphorylation and Pyruvate Oxidation
158 Respiratory Chain Disorders 614(6)
Salvatore DiMauro
159 Disorders of Energy Metabolism 620(2)
Juan M. Pascual
Salvatore DiMauro
Part 7 Organelle-Related Disorders
160 Mucopolysaccharidosis, Glycoproteinosis, and Mucolipidosis 622(11)
James Edmond Wraith
161 Sphingolipidoses 633(4)
Joe T. R. Clarke
162 Peroxisomal Disorders 637(5)
David Valle
Gerald V. Raymond
Stephen J. Gould
163 Congenital Disorders of Glycosylation 642(3)
Jaak Jaeken
Part 8 Disorders of Lipid and Bile Acid Metabolism
164 Disorders of Cholesterol Synthesis 645(2)
Peter T. Clayton
165 Disorders of Bile Acid Synthesis 647(4)
Peter T. Clayton
166 Disorders of Lipid and Lipoprotein Metabolism 651(11)
Peter O. Kwiterovich Jr
Part 9 Disorders of Nucleic Acids, Heme Metabolism, and Metals Transport
167 Disorders of Heme Biosynthesis: The Porphyrias 662(6)
Robert J. Desnick
168 Disorders of Purine and Pyrimidine Metabolism 668(5)
Georges van den Berghe
169 Disorders of Metal Metabolism 673(4)
Jean-Marie Saudubray
Section 12 Clinical Genetics and Dysmorphology
John C. Carey
Michael J. Bamshad
Part 1 The Genetic Approach to Disorders of Children
170 Key Principles in Human Genetics 677(7)
Michael J. Bamshad
Lynn B. Jorde
171 Multifactorial Inheritance 684(3)
Lynn B. Jorde
172 Principles of Care 687(1)
Claire O. Leonard
Part 2 Chromosomal Disorders
173 Human Cytogenetics 688(3)
Sarah T. South
John C. Carey
174 Chromosome Disorders 691(6)
John C. Carey
Part 3 Birth Defects, Malformations, and Syndromes
175 Birth Defects, Malformations, and Syndromes 697(3)
John C. Carey
Michael J. Bamshad
176 Syndromes of Multiple Congenital Anomalies/Dysplasias 700(5)
John C. Carey
177 Craniofacial Disorders 705(8)
Carrie Lyn Heike
Michael L. Cunningham
178 Approach to the Child with Birth Defects 713(3)
John C. Carey
Michael J. Bamshad
179 Genetic Skeletal Disorders 716(5)
John C. Carey
Michael J. Bamshad
180 Congenital Contractures 721(1)
Michael J. Bamshad
John C. Carey
181 Connective Tissue Dysplasias 722(6)
Alan Rope
182 Neurocutaneous Disorders 728(4)
David H. Viskochil
183 Environmental Causes of Birth Defects 732(7)
Elizabeth Balken
Marsha Leen-Mitchell
Lynn P. Martinez
Julia A. Robertson
184 Disorders of Accelerated Aging 739(3)
John C. Carey
185 Genetic Evaluation of Developmental Delay/Mental Retardation 742(7)
Agatino Battaglia
John C. Carey
Section 13 Immunologic Disorders
Talal A. Chatila
186 Overview of the Immune System 749(6)
Eli M. Eisenstein
Kathleen E. Sullivan
Calvin B. Williams
187 Undue Susceptibility to Infection 755(2)
Talal A. Chatila
188 Primary Immunodeficiencies 757(8)
Talal A. Chatila
189 Complement Disorders 765(4)
Patricia C. Giclas
Ashley A. Frazer-Abel
Section 14 Allergic Disorders
Talal A. Chatila
190 Allergic Disease and Atopy 769(2)
Talal A. Chatila
191 Clinical Aspects of Allergic Diseases 771(4)
Maria Garcia-Lloret
192 Allergic Rhinitis and Conjunctivitis 775(2)
Maria Garcia-Lloret
193 Anaphylaxis, Urticaria, and Angioedema 777(3)
Marc A. Riedel
194 Food Allergy 780(2)
Maria Garcia-Lloret
195 Insect Allergy 782(1)
Maria Garcia-Lloret
196 Latex Allergy 783(1)
Marc A. Riedel
197 Adverse Reactions to Drugs 784(3)
Marc A. Riedel
Section 15 Rheumatology
Robert P. Sundel
Part 1 General Principles in Rheumatology
198 Pathogenesis of Inflammatory and Autoimmune Disorders 787(5)
Kathleen E. Sullivan
199 History and Physical Examination in Rheumatology 792(3)
Robert P. Sundel
200 Diagnostic Testing in Rheumatology 795(5)
Peter A. Nigrovic
Part 2 Specific Rheumatologic Disorders
201 Juvenile Idiopathic Arthritis 800(6)
Carol A. Wallace
David A. Cabral
Robert P. Sundel
202 Spondyloarthropathies 806(4)
David A. Cabral
Lori B. Tucker
203 Vasculitides 810(4)
Karyl S. Barron
204 Systemic Lupus Erythematosus, Overlap Connective Tissue Diseases, and Mixed Connective Tissue Disease 814(4)
Earl D. Silverman
205 Juvenile Dermatomyositis 818(5)
Lisa G. Rider
206 Scleroderma 823(3)
Francesco Zulian
Part 3 Systemic Syndromes in Rheumatology
207 Musculoskeletal Pain Syndromes 826(4)
Yukiko Kimura
208 Chronic Fatigue Syndrome 830(2)
David S. Leslie
209 Autoinflammatory Disorders 832(7)
Philip J. Hashkes
Section 16 The Musculoskeletal System
John A. Herring
210 Growth and Development 839(2)
John G. Birch
211 The Limping Child 841(1)
Lawson A. B. Copley
212 Torsional and Angular Deformities 842(3)
Karl E. Rathjen
213 Disorders of the Foot 845(6)
Charles E. Johnston
214 Disorders of the Knee 851(1)
John A. Herring
215 Developmental Dysplasia of the Hip 852(4)
David A. Podeszwa
216 Disorders of the Neck and Spine 856(6)
Daniel J. Sucato
217 Disorders of the Upper Extremity 862(3)
Marybeth Ezaki
218 Injuries 865(5)
Philip Wilson
219 Tumors 870(2)
B. Stephens Richards
220 Neuromuscular Disorders 872(2)
Lori A. Karol
221 Common Orthopedic Misses 874(3)
John A. Herring
Section 17 Infectious Diseases
Anne A. Gershon
Peter J. Hotez
Part 1 Principles of Infectious Disease
222 Bacterial Pathogenesis 877(3)
Janet R. Gilsdorf
Carl F. Marrs
223 Bacteremia, Sepsis, and Septic Shock 880(3)
Stephanie H. Stovall
Richard F. Jacobs
224 Viral Pathogenesis 883(2)
Anne Moscona
Anne A. Gershon
225 Infection Control 885(3)
Margaret C. Fisher
226 Diagnostic Approaches for Infectious Diseases 888(5)
John C. Christenson
E. Kent Korgenski
227 Acute Fever without a Focus 893(2)
Steven Black
228 Fever of Unknown Origin 895(2)
Russell W. Steele
229 Fever and Infection in the Immunocompromised Patient 897(5)
David B. Haslam
Jeffrey Scott McKinney
230 Therapy for Perinatal and Neonatal Infections 902(11)
David W. Kimberlin
Debra L. Palazzi
Richard J. Whitley
Part 2 Infections of Organ Systems
231 Bacterial Infections of the Central Nervous System 913(6)
Thomas S. Murray
Robert S. Baltimore
232 Viral Infections of the Central Nervous System 919(4)
John F. Modlin
233 Sexually Transmitted Infections 923(11)
Loris Y. Hwang
Anna-Barbara Moscicki
Mary-Ann Shafer
234 Bone, Joint, Soft Tissue Infections 934(5)
Robin B. Churchill
Blanca E. Gonzalez
235 Cardiac Infections 939(6)
Janet A. Stockheim
Stanford T. Shulman
236 Gastrointestinal Infections 945(2)
Matthew B. Laurens
Michael S. Donnenberg
237 Infections of the Liver 947(3)
M. Kyle Jensen
Grzegorz Telega
238 Urinary Tract Infections 950(6)
Keith M. Krasinski
239 Catheter-Associated Infections 956(3)
Marc Foca
Part 3 Infections of the Respiratory System
240 Community-Acquired and Bacterial Pneumonia in Children 959(2)
Stephen I. Pelton
241 Viral Respiratory Infections Including Influenza 961(9)
J. Robert Honegger
Michael T. Brady
242 Fungal Respiratory Infections 970(3)
Hana Hakim
Aditya H. Gaur
243 Infections of the Ear 973(7)
Jerome O. Klein
Part 4 Treatment and Prevention of Infectious Diseases
244 Immunizations 980(12)
Kristina A. Bryant
245 Antiviral Therapy 992(4)
David K. Hong
Charles G. Prober
246 Antibacterial Therapy 996(15)
David K. Hong
Charles G. Prober
247 Antifungal Therapy 1011(5)
Patricia M. Flynn
Part 5 Bacterial Infections
248 Actinomycosis 1016(2)
Nahed Abdel-Haq
Ashir Kumar
249 Anaerobic Infections 1018(3)
Ayesha Mirza
Mobeen H. Rathore
250 Clostridial Infections 1021(2)
Jose Zayas
Mobeen H. Rathore
251 Anthrax (Bacillus anthracis) 1023(1)
Denise Bratcher
252 Arcanobacterium 1024(1)
Dennis L. Murray
253 Bacillus cereus 1024(1)
Denise Bratcher
254 Brucellosis 1025(1)
Ziad M. Shehab
255 Burkholderia and Pseudomonas 1026(1)
Jane L. Burns
256 Campylobacter 1027(1)
Guillermo M. Ruiz-Palacios
257 Cat Scratch Disease (Bartonella henselae) 1028(2)
Moshe Ephros
Michael Giladi
258 Chancroid (Hemophilus ducreyi) 1030(1)
Mary Allen Staat
259 Chlamydia 1031(3)
Navjyot K. Vidwan
Mary Allen Staat
260 Cholera 1034(2)
Chokechai Rongkavilit
Ashir Kumar
261 Diphtheria 1036(2)
Gary D. Overturf
262 Enterococcus 1038(1)
Dwight A. Powell
263 Haemophilus influenzae 1039(4)
Mark R. Schleiss
Arnold L. Smith
264 Legionella Pneumonia 1043(1)
Lorry G. Rubin
265 Leptospirosis 1044(1)
Anne A. Gershon
Michael Katz
266 Listeriosis 1045(1)
Ziad M. Shehab
267 Lyme Disease 1046(2)
Michael A. Gerber
268 Moraxella catarrhalis 1048(1)
Basim I. Asmar
269 Tuberculosis (Mycobacteria tuberculosis) 1049(9)
Jeffrey R. Starke
270 Nontuberculous Mycobacterial Infections 1058(3)
Jeffrey R. Starke
271 Leprosy 1061(3)
Wayne M. Meyers
Francoise Portaels
Douglas S. Walsh
272 Buruli Ulcer (Mycobacterium ulcerans Infection) 1064(2)
Wayne M. Meyers
Francoise Portaels
Douglas S. Walsh
273 Mycoplasma Infections 1066(2)
Julia A. McMillan
274 Neisseria gonorrhoeae 1068(2)
Mary Allen Staat
275 Neisseria meningitidis 1070(3)
Michele Estabrook
276 Nocardiosis 1073(1)
Nahed Abdel-Haq
Ashir Kumar
277 Pasteurella multocida 1074(1)
Morven S. Edwards
278 Pertussis 1075(2)
Beverly L. Connelly
279 Plague 1077(1)
Gary D. Overturf
280 Pneumococcal Infections 1078(2)
Sandra R. Arnold
P. Joan Chesney
281 Rat-Bite Fever 1080(1)
Lorry G. Rubin
282 Relapsing Fever 1081(176)
Dennis L. Murray
358 Disorders of the Epidermis 1257(6)
Kristen B. Holland
359 Disorders of the Dermis and Subcutaneous Tissue 1263(1)
Anita N. Haggstrom
360 Genetic Disorders of the Skin 1264(7)
Brook E. Tlougan
Amy S. Paller
361 Melanocytic Lesions and Disorders of Pigmentation 1271(6)
Julie V. Schaffer
Seth J. Orlow
362 Immunologic Diseases 1277(5)
Julie Prendiville
363 Neoplastic and Proliferative Disorders 1282(1)
Victoria R. Barrio
Lawrence F. Eichenfield
364 Vascular Tumors and Malformations 1283(4)
Ilona J. Frieden
Sheilagh M. Maguiness
365 Acne and Other Disorders of the Pilosebaceous Unit 1287(3)
Sara W. Dill
Bari B. Cunningham
366 Disorders of Nails 1290(1)
Liborka Kos
367 Skin Infections and Exanthems 1291(10)
Jane S. Bellet
Anthony J. Mancini
368 Infestations 1301(4)
Denise W. Metry
Section 19 Disorders of the Ear, Nose, and Throat
Joseph Kerschner
369 The Ear 1305(12)
John H. Greinwald Jr.
Margaret A. Kenna
Blake C. Papsin
370 Nose and Sinus 1317(7)
Ellen S. Deutsch
Cecille G. Sulman
371 The Pharynx and Upper Airway 1324(11)
Marshall E. Smith
372 The Head, Face, and Neck 1335(3)
Craig S. Derkay
Michael J. Cunningham
373 Head and Neck Masses 1338(5)
David E. Tunkel
Jonathan A. Perkins
Section 20 Disorders of the Oral Cavity
Howard L. Needleman
Stephen Shusterman
374 Dental Caries 1343(3)
Man Wai Ng
Isabelle I. Chase
375 Dental Emergency Care 1346(4)
Howard L. Needleman
Brian Grove
376 Dental Occlusion and Its Management 1350(4)
Richard Bruun
Sivabalan Vasudavan
377 Periodontal and Gingival Health and Diseases 1354(2)
Nadeem Y. Karimbux
David M. Kim
378 Oral Pathology 1356(5)
Andrew L. Sonis
Brian Grove
379 Temporomandibular Joint Disorders 1361(1)
Bonnie L. Padwa
380 Behavioral Treatment Options in Pediatric Dentistry 1362(3)
Stephen Shusterman
Linda P. Nelson
Section 21 Disorders of the Gastrointestinal System
Colin D. Rudolph
Part 1 Presenting Signs and Symptoms
381 Normal Structure and Function of the Gastrointestinal Tract 1365(7)
Alan N. Mayer
382 Approach to the Child with Acute, Chronic, or Cyclic Vomiting 1372(3)
B U. K. Li
383 Acute Abdominal Pain 1375(2)
J. Craig Egan
John J. Aiken
Colin D. Rudolph
384 Chronic Abdominal Pain 1377(4)
Adrian Miranda
385 Diarrhea 1381(5)
Ricardo A. Caicedo
Ivor D. Hill
386 Constipation and Fecal Incontinence 1386(3)
Manu R. Sood
387 Upper and Lower Gastrointestinal Bleeding 1389(2)
Richard J. Noel
388 Abdominal Masses 1391(3)
John C. Densmore
Keith T. Oldham
389 Gastrointestinal Obstruction 1394(2)
Pradeep Nazarey
Thomas T. Sato
390 Protein-Losing Enteropathy 1396(2)
Richard J. Noel
391 Gastrointestinal Disorders Associated with Immunodeficiency 1398(2)
Richard J. Noel
Part 2 Esophageal Disorders
392 Anatomic Disorders of the Esophagus 1400(3)
Dave R. Lai
393 Disorders of Esophageal Motility 1403(2)
Neelesh A. Tipnis
394 Gastroesophageal Reflux and Other Causes of Esophageal Inflammation 1405(7)
Colin D. Rudolph
395 Other Esophageal Disorders 1412(3)
Tonya Adamiak
Colin D. Rudolph
Part 3 Congenital and Anatomic Disorders of the Stomach and Intestine
396 Abdominal Wall Defects 1415(2)
Danielle B. Peterson
Marjorie J. Area
397 Malrotation and Volvulus 1417(3)
John J. Aiken
398 Infantile Hypertrophic Pyloric Stenosis 1420(1)
Rachel Adams Greenup
Casey M. Calkins
399 Congenital Atresias, Stenosis, and Webs 1421(1)
Andrea Winthrop
Jill Whitehouse
400 Microgastria and Gastric Perforation 1422(1)
Andrea Winthrop
Jill Whitehouse
401 Duplications and Cysts 1423(2)
Denise B. Klinkner
David M. Gourlay
402 Omphalo-Mesenteric Duct Remnants 1425(2)
Denise B. Klinkner
David M. Gourlay
403 Meconium Diseases of Infancy and Distal Intestinal Obstruction Syndrome 1427(1)
Pradeep Nazarey
Thomas T. Sato
404 Intussusception 1428(1)
John C. Densmore
Dave R. Lal
405 Inguinal and Other Hernias 1429(3)
John J. Aiken
406 Superior Mesenteric Artery Syndrome 1432(1)
Vincent P. Biank
407 Motor Disorders of the Stomach, Small Bowel, and Colon 1433(5)
Manu R. Sood
Casey M. Calkins
Part 4 Disorders of Digestion and Absorption
408 Disorders of Digestion and Absorption 1438(16)
Ivor D. Hill
Ricardo A. Caicedo
Part 5 Disorders of the Stomach and Intestine
409 Inflammatory Disorders of the Stomach 1454(6)
Ranjan Dohil
Eric Hassall
410 Inflammatory Bowel Disease 1460(8)
Michael C. Stephens
Subra Kugathasan
Thomas T. Sato
411 Allergic and Eosinophilic Gastroenteropathies 1468(3)
B U. K. Li
412 Vascular, Systemic, and Other Disorders Affecting the Gastrointestinal Tract 1471(2)
Grzegorz Telega
Vincent F. Blank
B U. K. Li
413 Acute Appendicitis, Typhlitis, and Chronic Appendicitis 1473(2)
J. Craig Egan
John J. Aiken
Grzegorz Telega
B U. K. Li
414 Polyps and Tumors of the Gastrointestinal Tract 1475(5)
Steven H. Erdman
Edward J. Hoffenberg
415 Congenital Anomalies of the Anorectum 1480(2)
Casey M. Calkins
Manu R. Sood
416 Other Anorectal Disorders 1482(3)
Judith M. Sondheimer
Part 6 The Exocrine Pancreas
417 Disorders of the Exocrine Pancreas 1485(6)
Steven L. Werlin
Section 22 Disorders of the Liver and Biliary Tract
Saul Karpen
418 Structure and Function of the Liver 1491(4)
Jonathan E. Teitelbaum
419 Evaluation of the Infant and Child with Liver Disease 1495(6)
Robert H. Squires Jr
420 Autoimmune Disorders of the Liver 1501(2)
Nada Yazigi
421 Metabolic and Genetic Disorders of the Liver 1503(9)
Frederick J. Suchy
422 Drug, Toxin, and TPN Liver Disease 1512(3)
Christopher D. Jolley
Regino P. Gonzalez-Peralta
Beth A. Carter
423 The Liver in Systemic Disease 1515(2)
Maureen M. Jonas
424 Acute Liver Failure 1517(3)
Vicky Lee Ng
425 End-Stage Liver Disease 1520(4)
Vicky Lee Ng
426 Other Disorders of the Liver 1524(3)
Stephanie Abrams
Gregorz Telega
427 The Biliary Tract 1527(8)
Colin D. Rudolph
Gregorz Telega
Vincent F. Blank
Douglas S. Fishman
Section 23 Disorders of the Blood
George R. Buchanan
Part 1 Principles of Blood Disorders
428 Approach to Suspected Hematologic Disorders 1535(3)
George R. Buchanan
429 Hematopoeisis 1538(4)
Charles T. Quinn
Part 2 Disorders of Red Blood Cells and Anemia
430 Anemia 1542(4)
Matthew M. Heeney
431 Iron Deficiency 1546(3)
Matthew M. Heeney
432 Anemia Due to Diminished Red Blood Cell Production 1549(3)
Zora R. Rogers
433 Hemolytic Anemia 1552(4)
Amber Mayfield Yates
Russell E. Ware
434 Hemoglobinopathies 1556(11)
Charles T. Quinn
Part 3 Disorders of Coagulation and Platelets
435 Normal and Abnormal Hemostasis 1567(3)
Janna M. Journeycake
Janet Yang
Anthony K. C. Chan
436 Inherited Bleeding Disorders 1570(4)
Amy L. Dunn
Shannon L. Meeks
Thomas C. Abshire
437 Acquired Coagulation Disorders 1574(3)
Guy Young
438 Diagnosis and Management of Thrombosis 1577(4)
Janna M. Journeycake
Anthony K. C. Chan
439 Disorders of Platelets 1581(6)
Cindy E. Neunert
Donald L. Yee
Part 4 Disorders of the Spleen and Lymph Nodes
440 The Spleen and Lymph Nodes 1587(3)
Shelley E. Crary
Part 5 Disorders of White Blood Cells
441 Disorders of Granulocytes 1590(7)
R. Alexander Blackwood
Lawrence A. Boxer
Part 6 Principles of Transfusion
442 Transfusion Medicine 1597(6)
Cassandra D. Josephson
Section 24 Neoplastic Disorders
Robert J. Arced
Part 1 Principles of Oncology
443 Cancer Genetics and Biology 1603(4)
David Malkin
444 Epidemiology of Childhood Cancer 1607(1)
Louise Parker
445 Chemotherapy and Radiation Therapy 1608(4)
Peter C. Adamson
Larry E. Kun
446 Clinical Trials in Pediatric Oncology 1612(2)
Malcolm A. Smith
Gregory H. Reaman
447 Neonatal Oncology 1614(2)
Sheila Weitzman
Yaron Finkelstein
Robert J. Arceci
448 Cancer Survivorship and Recommendations for Follow-Up 1616(4)
Smita Bhatia
Anna T. Meadows
Part 2 Hematologic Malignancies
449 Acute Lymphoblastic Leukemia 1620(5)
James B. Nachman
450 Myeloid Malignancies 1625(5)
Soheil Meshinchi
Robert J. Arceci
Howard J. Weinstein
451 Non-Hodgkin Lymphoma 1630(2)
Mitchell S. Cairo
Thomas G. Gross
452 Hodgkin Lymphoma 1632(5)
Melissa M. Hudson
Tanya M. Trippett
Part 3 Solid Tumors
453 Osteosarcoma 1637(2)
Richard Gorlick
Paul A. Meyers
454 Ewing Sarcoma and Primitive Neuroectodermal Tumor 1639(2)
Crystal L. Mackall
Jeffrey A. Toretsky
455 Rhabdomyosarcoma 1641(3)
Douglas S. Hawkins
Frederic G. Ban
456 Renal Tumors 1644(3)
Elizabeth Mullen
457 Neuroblastoma 1647(4)
Michael D. Hogarty
Garrett M. Brodeur
458 Malignant Liver Tumors 1651(3)
Gail E. Tomlinson
Howard M. Katzenstein
459 Germ Cell Tumors 1654(2)
Thomas A. Olson
460 Brain Tumors and Spinal Tumors 1656(5)
Kenneth J. Cohen
Ian F. Pollack
461 Retinoblastoma 1661(1)
Rima F. Jubran
Anna T. Meadows
462 Vascular Neoplasms 1662(2)
Denise M. Adams
Michael E. Kelly
Part 4 Mononuclear Phagocytic System Disorders
463 Histiocytic Disorders 1664(5)
R. Maarten Egeler
Robert J. Arceci
Jan-Inge Henter
Section 25 Disorders of the Kidney and Urinary Tract
Norman D. Rosenblum
Part 1 Principles of Nephrology
464 Renal Morphogenesis 1669(2)
Sunder Sims-Lucas
Carlton M. Bates
465 Development of Renal Function 1671(6)
Tino D. Piscione
466 Fluid, Electrolyte, and Acid-Base Disorders 1677(9)
Manjula Gowrishankar
467 Diagnostic Approach to Renal Disease 1686(5)
John W. Foreman
Part 2 Abnormalities of the Kidney and Urinary Tract
468 Kidney or Urinary Tract Disorders 1691(6)
John W. Foreman
469 Renal Malformations 1697(3)
Norman D. Rosenblum
470 Cystic Diseases of the Kidney 1700(6)
Friedhelm Hildebrandt
471 Acute Renal Failure 1706(4)
Prasad Devarajan
472 Glomerular Diseases 1710(19)
Allison A. Eddy
473 Hereditary Glomerulopathies 1729(3)
Clifford E. Kashtan
474 Renal Tubular Disorders 1732(6)
Michel Baum
475 Urinary Tract Stone Diseases 1738(3)
Valerie Langlois
476 Urologie Abnormalities of the Genitourinary Tract 1741(8)
Luis H. P. Braga
Darius J. Bagli
Part 3 Chronic Kidney Disease
477 Chronic Kidney Disease 1749(6)
Denis F. Geary
478 Chronic Dialysis 1755(2)
Stuart L. Goldstein
479 Systemic Hypertension 1757(12)
Craig W. Belsha
Joseph T. Flynn
Section 26 Disorders of the Cardiovascular System
Julien I. E. Hoffman
David F. Teitel
Part 1 Principles of Cardiology
480 Development of the Cardiovascular System 1769(6)
Deepak Srivastava
481 Genetics of Heart Disease 1775(7)
Kathleen M. Ruppel
Part 2 Approach to the Patient with Cardiovascular Disease
482 Fetal Cardiology 1782(7)
Lisa K. Hornberger
Jean Trines
483 Neonate and Infant with Cardiovascular Disease 1789(15)
David F. Teitel
484 Congenital Heart Disease 1804(31)
Julien I. E. Hoffman
485 Arrhythmias 1835(13)
George F. Van Hare
486 Child and Adolescent with Cardiovascular Disease 1848(7)
Howard P. Gutgesell
George M. McDaniel
Part 3 Acquired Cardiovascular Disease
487 Cardiac Tumors 1855(1)
Julien I. E. Hoffman
488 Kawasaki Disease 1855(3)
Mary Beth Son
Jane W. Newburger
489 Diseases of Myocardium 1858(3)
Jeffrey A. Towbin
490 Infective Endocarditis 1861(2)
Jane W. Newburger
491 Pericardial Diseases 1863(4)
Julien I. E. Hoffman
492 Pulmonary Hypertension 1867(2)
Julien I. E. Hoffman
Part 4 Diagnostic Tools in Heart Disease
493 Electrocardiography 1869(4)
George F. Van Hare
494 Radiologic Imaging 1873(6)
Alison Knauth Meadows
Michael W. Dae
495 Echocardiography 1879(4)
Theresa A. Tacy
496 Cardiac Catherization 1883(4)
Phillip Moore
Part 5 Management of Patients with Cardiovascular Disease
497 Heart Failure 1887(6)
Robert E. Shaddy
Chitra Ravishankar
498 The Patient with Single Ventricle 1893(4)
Jacqueline Kreutzer
499 Interventional Cardiology 1897(6)
Phillip Moore
500 Health Care Management for the Child with Cardiovascular Disease 1903(3)
Mark Cocalis
501 Sports Screening for Cardiovascular Risk 1906(3)
Mark Cocalis
Julien I. E. Hoffman
Section 27 Disorders of the Respiratory System
Jay K. Kolls
Part 1 Principles of Pulmonology
502 Lung Growth in Infancy and Childhood 1909(4)
Richard L. Auten
503 Physiologic Basis of Pulmonary Function 1913(4)
Daniel J. Weiner
504 Global Burden of Respiratory Infections and Mucosal Immunology of the Respiratory Tract 1917(3)
Jay K. Kolls
Joseph P. Mizgerd
505 Clinical Presentation of Respiratory Illness 1920(4)
Hans Pasterkamp
506 Tools for Diagnosis and Management of Respiratory Disease 1924(4)
Beverley Newman
Geoffrey Kurland
Part 2 Disorders of the Respiratory System
507 Congenital Disorders of the Lower Airways and Mediastinum 1928(5)
Andrew Bush
508 Disorders of Respiratory Control and Sleep-Disordered Breathing 1933(9)
David Gozal
Leila Kheirandish-Gozal
509 Sleep Disorders 1942(7)
Hemant Sawnani
Narong Simakajornboon
510 Disorders Causing Airway Obstruction 1949(9)
Shean J. Aujla
Jonathan E. Spahr
511 Aspiration Syndromes 1958(4)
Cori L. Daines
512 Asthma 1962(12)
Gurjit K. Khurana Hershey
513 Bronchopulmonary Dysplasia 1974(3)
Timothy D. Murphy
514 Cystic Fibrosis 1977(9)
David M. Orenstein
515 Interstitial Lung Disease 1986(3)
Jennifer A. Rama
Leland L. Fan
516 Alpha-1 Antitrypsin Deficiency Lung Disease 1989(1)
Terence R. Flotte
Christian Mueller
517 Pulmonary Vasculitis Syndromes 1990(3)
Paul Rosen
518 Pulmonary Alveolar Proteinosis 1993(3)
Bruce C. Trapnell
Lisa R. Young
519 Chest Wall and Respiratory Muscle Disorders 1996(5)
Jonathan D. Finder
Section 28 Disorders of the Endocrine System
Allen W. Root
520 Mechanisms of Hormone Action 2001(8)
Adda Grimberg
Linda A. DiMeglio
521 Disorders of the Anterior Pituitary Gland 2009(3)
Edward O. Reiter
522 Growth and Growth Impairment 2012(5)
Edward O. Reiter
523 Endocrine Abnormalities Causing Growth Impairment 2017(6)
Edward O. Reiter
524 Tall Stature 2023(1)
Edward O. Reiter
525 Primary Disturbances in Water Homeostasis 2024(4)
Abhinash Srivatsa
Joseph A. Majzoub
526 The Thyroid 2028(3)
Delbert A. Fisher
527 Hypothyroidism in the Infant 2031(6)
Delbert A. Fisher
528 Acquired Hypothyroidism 2037(2)
Delbert A. Fisher
529 Hyperthyroidism 2039(2)
Delbert A. Fisher
530 Other Disorders of the Thyroid 2041(2)
Delbert A. Fisher
531 The Adrenal Cortex 2043(3)
Walter L. Miller
532 Evaluation of Adrenal Function 2046(2)
Walter L. Miller
533 Genetic Lesions in Steroidogenesis 2048(4)
Walter L. Miller
534 Adrenal Insufficiency 2052(3)
Walter L. Miller
535 Adrenal Excess 2055(2)
Walter L. Miller
536 Glucocorticoid Therapy and Withdrawal 2057(1)
Walter L. Miller
537 Endocrine Neoplasia Syndromes 2058(4)
Steven D. Chernausek
Constantine A. Stratakis
538 Normal Human Sex Differentiation 2062(1)
Melvin M. Grumbach
539 Disorders of Sexual Development (DSD) 2063(11)
Melvin M. Grumbach
540 Normal Pubertal Development 2074(3)
Dennis M. Styne
Leonna Cuttler
541 Abnormal Pubertal Development 2077(9)
Dennis M. Styne
Leonna Cuttler
542 Calcium, Phosphorus, and Magnesium Metabolism 2086(11)
Allen W. Root
543 Disorders of Bone Formation 2097(7)
Allen W. Root
544 Diabetes Mellitus 2104(21)
Arlan L. Rosenbloom
545 Endocrine Causes of Hypoglycemia 2125(6)
Andrea Kelly
Charles A. Stanley
Section 29 Disorders of the Nervous System
Scott L. Pomeroy
Blaise F. D. Bourgeois
Basil T. Darras
Edward M. Kaye
Part 1 Principles of Neurology
546 Introduction to Neurology 2131(2)
Mustafa Sahin
547 Clinical Approach to Neurologic Disease 2133(16)
Maitreyi Mazumdar
Part 2 Abnormal Development of the Nervous System
548 Cranial Developmental Abnormalities 2149(5)
Omar Khwaja
549 Disturbances of the Neural Tube and Spine Closure 2154(2)
Omar Khwaja
550 Macrocephaly and Microcephaly 2156(2)
Nicole J. Ullrich
Part 3 Acute Deterioration of Neurologic Function
551 Trauma to the Nervous System 2158(7)
Magdi M. Sobeih
552 Stroke and Cerebrovascular Disease 2165(9)
Michael J. Rivkin
553 Hydrocephalus and Pseudotumor Cerebri 2174(4)
Nicole J. Ullrich
554 Cerebral Palsy and Static Encephalopathies 2178(4)
Robert S. Rust
David K. Urion
555 Infections of the Central Nervous System 2182(6)
Kiran P. Maski
Nicole J. Ullrich
556 Immune- and Inflammatory-Mediated Central Nervous System Syndromes 2188(10)
Mark P. Gorman
Part 4 Epilepsy
557 Epidemiology of Epilepsy, Seizure Classification, Epilepsy Syndromes 2198(4)
Mark H. Libenson
Ann M. Bergin
558 Etiologies of Epilepsies 2202(2)
Annapurna Poduri
559 Febrile Seizures 2204(2)
Masanori Takeoka
560 Evaluation of New Onset Seizures 2206(1)
Alexander Rotenberg
561 Status Epilepticus 2206(2)
Alexander Rotenberg
562 Epilepsy Treatment: Antiepileptic Drug Therapy 2208(5)
Blaise F. D. Bourgeois
563 Epilepsy Treatment: Ketogenic Diet and Neurostimulation 2213(1)
Ann M. Bergin
564 Epilepsy Treatment: Surgery 2214(2)
Dean P. Sarco
Part 5 Paroxysmal Disorders
565 Migraine and Headache Disorders 2216(3)
Alyssa Ann LeBel
Anna Minster
566 Movement Disorders, Tics, and Tourette Syndrome 2219(4)
Diana Apetauerova
567 Other Paroxysmal Disorders 2223(1)
Sanjeev V. Kothare
Part 6 Disorders of Strength, Tone, and Sensation
568 General Evaluation of Strength, Tone, and Sensation 2224(2)
Peter B. Kang
Basil T. Darras
569 The Hypotonic Infant 2226(2)
Basil T. Darras
570 Peripheral Nerve Disorders and Anterior Horn Cell Diseases 2228(7)
Peter B. Kang
571 Diseases of the Neuromuscular Junction 2235(6)
H. Royden Jones Jr
572 Myopathies 2241(7)
Basil T. Darras
Part 7 Developmental Delay and Regression
573 Neurologic Aspects of Disorders of Metal Metabolism 2248(2)
Cecilia Mellado
Mustafa Sahin
574 Lysosomal Storage Disorders 2250(6)
Irina A. Anselm
575 Rett Syndrome (MECP2-Related Disorders) 2256(1)
Cecilia Mellado
Mustafa Sahin
576 Leukoencephalopathies 2257(8)
Mark P. Gorman
577 Neurotransmitter Disorders 2265(4)
Erika Fulhvood Augustine
Annapurna Poduri
578 Phakomatoses 2269(4)
Mustafa Sahin
Section 30 Disorders of the Eyes
Alex V. Levin
Part 1 General Principles
579 Anatomy and Physiology of the Eye and Ocular System 2273(2)
Monte A. Del Monte
580 Office Evaluation of the Eyes 2275(4)
Gregg T. Lueder
581 Special Tests of the Eyes 2279(3)
Daniel J. Karr
Alex V. Levin
582 International Pediatric Ophthalmology 2282(2)
Sherwin J. Isenberg
Leonard Apt
Part 2 Disorders of the Eye
583 Eye Emergencies and Trauma 2284(5)
Daniel J. Karr
Alex V. Levin
584 Visual Impairment in Childhood 2289(2)
David S. Walton
585 Amblyopia 2291(2)
Anthony G. Quinn
Alex V. Levin
586 Strabismus 2293(5)
Robert W. Enzenauer
Mary Ellen Hoehn
Monte A. Del Monte
587 The Eye in Child Abuse 2298(2)
Alex V. Levin
588 Red Eye 2300(4)
Anthony G. Quinn
589 Lid and Lacrimal System Disorders 2304(4)
Gregg T. Lueder
590 Anterior Segment Disorders 2308(5)
David S. Walton
591 Retinopathy of Prematurity 2313(3)
Earl A. Palmer
Irene Hsu-Dresden
592 Genetic Eye Diseases 2316(10)
J. Bronwyn Bateman
John Roarty
Christina L. Butera
Alex V. Levin
593 Optic Nerve Disorders 2326(5)
John Roarty
Index 2331
Contributors xxvii
Preface liii
Acknowledgments lv
Section 1 Fundamentals of Pediatrics
Thomas G. DeWitt
1 Role of the Pediatrician 1(2)
Thomas G. DeWitt
Neal Halfon
2 Decision Making: Use of Evidence-Based Medicine 3(2)
Suresh Nagappan
Kenneth B. Roberts
3 Communication 5(7)
Elizabeth A. Rider
4 Interviewing Techniques 12(3)
Christopher F. Boiling
5 Systems of Practice and Office Management 15(2)
Peter Margolis
6 Core Competencies 17(2)
Theodore C. Sectish
7 Patient and Family-Centered Care 19(2)
Jeffrey M. Simmons
Stephen E. Muething
Kathleen L. Dressman
8 Disaster Preparedness 21(3)
Janet M. Berreman
Linda Rudolph
9 Law, Ethics, and Clinical Judgment 24(3)
Angela Roddey Holder
Section 2 Health Promotion and Disease Prevention
Eve R. Colson
Part 1 Health Maintenance Issues
10 Well-Child Care 27(7)
Judith S. Shaw
Judith S. Palfrey
11 Child Development 34(8)
Ilgi Ozturk Ertem
Carol Cohen Weitzman
12 Screening 42(5)
Ada M. Fenick
13 Oral Health Supervision 47(5)
Ada M. Fenick
Linda P. Nelson
14 Complementary and Alternative Medicine (CAM) 52(8)
Anju Sawni
15 Culture and Pediatric Practice 60(3)
Sakena Abedin
16 Gay and Lesbian Parents 63(3)
Cindy M. Schorzman
Melanie A. Gold
17 Environmental Pediatrics 66(6)
Ruth A. Etzel
18 Travel Medicine 72(5)
Joseph A. Zenel
Chandy C. John
Part 2 Managing Family Transition
19 Family Function and Birth of a Child 77(2)
William I. Cohen
20 Foster Care and Adoption 79(5)
Brad D. Berman
Carol Cohen Weitzman
21 Family Discord and Divorce 84(2)
Michael Jellinek
22 Supporting the Grieving Child and Family 86(3)
David J. Schonfeld
Section 3 Nutrition
Praveen S. Goday
23 Normal Nutritional Requirements 89(6)
Praveen S. Goday
24 Breast-Feeding 95(4)
Jane Morton
Ruth A. Lawrence
25 Infant Formula and Complementary Foods 99(6)
Margaret Kirby
26 Postdischarge Nutritional Management of the Premature Infant 105
Utpala G. Das
Contributors xxvii
Preface liii
Acknowledgments lv
Section 1 Fundamentals of Pediatrics
Thomas G. DeWitt
1 Role of the Pediatrician 1(2)
Thomas G. DeWitt
Neal Halfon
2 Decision Making: Use of Evidence-Based Medicine 3(2)
Suresh Nagappan
Kenneth B. Roberts
3 Communication 5(7)
Elizabeth A. Rider
4 Interviewing Techniques 12(3)
Christopher F. Boiling
5 Systems of Practice and Office Management 15(2)
Peter Margolis
6 Core Competencies 17(2)
Theodore C. Sectish
7 Patient and Family-Centered Care 19(2)
Jeffrey M. Simmons
Stephen E. Muething
Kathleen L. Dressman
8 Disaster Preparedness 21(3)
Janet M. Berreman
Linda Rudolph
9 Law, Ethics, and Clinical Judgment 24(3)
Angela Roddey Holder
Section 2 Health Promotion and Disease Prevention
Eve R. Colson
Part 1 Health Maintenance Issues
10 Well-Child Care 27(7)
Judith S. Shaw
Judith S. Palfrey
11 Child Development 34(8)
Ilgi Ozturk Ertem
Carol Cohen Weitzman
12 Screening 42(5)
Ada M. Fenick
13 Oral Health Supervision 47(5)
Ada M. Fenick
Linda P. Nelson
14 Complementary and Alternative Medicine (CAM) 52(8)
Anju Sawni
15 Culture and Pediatric Practice 60(3)
Sakena Abedin
16 Gay and Lesbian Parents 63(3)
Cindy M. Schorzman
Melanie A. Gold
17 Environmental Pediatrics 66(6)
Ruth A. Etzel
18 Travel Medicine 72(5)
Joseph A. Zenel
Chandy C. John
Part 2 Managing Family Transition
19 Family Function and Birth of a Child 77(2)
William I. Cohen
20 Foster Care and Adoption 79(5)
Brad D. Berman
Carol Cohen Weitzman
21 Family Discord and Divorce 84(2)
Michael Jellinek
22 Supporting the Grieving Child and Family 86(3)
David J. Schonfeld
Section 3 Nutrition
Praveen S. Goday
23 Normal Nutritional Requirements 89(6)
Praveen S. Goday
24 Breast-Feeding 95(4)
Jane Morton
Ruth A. Lawrence
25 Infant Formula and Complementary Foods 99(6)
Margaret Kirby
26 Postdischarge Nutritional Management of the Premature Infant 105(2)
Utpala G. Das
27 Nutritional Issues: Toddler to Adolescent 107(3)
Margaret Kirby
Praveen S. Goday
28 Assessment of Nutritional Adequacy 110(1)
Praveen S. Goday
29 Malnutrition and Refeeding 111(3)
Praveen S. Goday
30 Poor Weight Gain 114(3)
Karen A. Francolla
Praveen S. Goday
31 Approach to the Infant and Child with Feeding Difficulty 117(6)
Richard J. Noel
32 The Overweight or Obese Child 123(3)
Michelle Smith-Beckley
Brian M. Fidlin
33 Specialized Nutrition Support 126(8)
Praveen S. Goday
34 Nutritional Access Devices 134(3)
Lillian Sablan
Karen Sherry
Section 4 Abuse, Neglect, Violence
John M. Leventhal
35 Child Maltreatment: Neglect to Abuse 137(7)
John M. Leventhal
Andrea G. Asnes
36 Family and Community Violence 144(6)
Renee Boynton-Jarrett
Robert Sege
37 Child Abuse Prevention: What Pediatricians Can Do 150(5)
Wendy Gwirtzman Lane
Howard Dubowitz
Section 5 Newborn
Alan H. Jobe
James M. Greenberg
Part 1 Care of the Newborn
38 Historical Perspectives 155(1)
James M. Greenberg
39 Care of the Fetus 155(3)
Alan H. Jobe
40 Fetal Disorders 158(2)
Timothy M. Crombleholme
Foong-Yen Lim
41 Neonatal Mortality and Morbidity 160(4)
Avroy A. Fanaroff
42 Delivery Room Resuscitation 164(6)
Myra H. Wyckoff
43 Transitional Changes in the Newborn 170(4)
David P. Carlton
44 Examination of the Newborn Infant 174(10)
Joseph A. Zenel
45 Postnatal Care and Observation 184(6)
Anthony E. Burgos
Part 2 Infants at Risk
46 Multiple Births 190(1)
James M. Greenberg
47 The Small-for-Gestational-Age Infant 191(4)
William W. Hay Jr
48 Infant of a Diabetic Mother 195(4)
Heather Morein French
Rebecca A. Simmons
Part 3 Specific Neonatal Conditions
49 Approach to the Cyanotic Infant 198(3)
Robin H. Steinhorn
50 Abnormalities of the Lungs 201(10)
M. Grisel Galarza
Ilene R. S. Sosenko
51 Metabolic Abnormalities 211(10)
William W. Hay Jr
52 Brain Abnormalities and Injuries 221(5)
Seetha Shankaran
C. Michael Cotton
53 Hematologic Abnormalities and Jaundice 226(7)
Henry C. Lee
Ashima Madan
Part 4 Disorders Specifically Related to Preterm Birth
54 Respiratory Distress Syndrome 233(5)
Thomas N. Hansen
Samuel Hawgood
55 Patent Ductus Arteriosus and Ductus Venosus 238(4)
Ronald I. Clyman
56 Hemodynamics 242(4)
Nick Evans
57 Necrotizing Enterocolitis 246(3)
Barbara Warner
58 Intraventricular Hemorrhage 249(4)
Henrietta S. Bada
59 Bronchopulmonary Dysplasia 253(3)
Alan H. Jobe
60 Emergencies 256(2)
James M. Greenberg
61 Special Intensive Care 258(3)
Thomas A. Parker
62 Outcomes of Preterm and Term Infants 261(4)
Marilee C. Allen
Section 6 Principles of Adolescent Care
Charles E. Irwin Jr.
Mary-Ann Shafer
Anna-Barbara Moscicki
Part 1 Growth and Development
63 Somatic Growth and Development 265(2)
Charles E. Irwin Jr.
64 Reproductive Growth and Development in the Female Adolescent 267(2)
Melissa Slivka
Anna-Barbara Moscicki
Mary-Ann Shafer
65 Reproductive Growth and Development in the Male Adolescent 269(2)
David J. Breland
Mark L. Rubinstein
66 Psychological Development 271(1)
Elizabeth M. Ozer
Charles E. Irwin Jr.
67 The Adolescent Visit 272(5)
Charles E. Irwin Jr.
Part 2 Health Problems of Adolescents
68 Mortality 277(1)
Elizabeth M. Ozer
69 Morbidity 277(1)
Charles E. Irwin Jr.
70 Sexual Behavior 278(1)
Erica B. Monasterio
71 Substance Use and Abuse 278(4)
Stephanie N. Crewe
Arik V. Marcell
Part 3 Mental Health Disorders in the Adolescent
72 Depression, Anxiety, and Other Disorders 282(6)
Kim Peter Norman
73 Disorders of Eating 288(4)
Kim Peter Norman
Sara M. Buckelew
Andrea K. Garber
Part 4 Reproductive Health Problems
74 Breast Masses 292(2)
Jennifer C. Edman
Mary-Ann Shafer
75 Scrotal Masses 294(2)
David J. Breland
Mark L. Rubinstein
76 Menstrual Problems 296(3)
Jennifer C. Edman
Mary-Ann Shafer
77 Intrauterine and Ectopic Pregnancy 299(2)
Erica B. Monasterio
Mary-Ann Shafer
78 Contraception 301(4)
Erica B. Monasterio
Mary-Ann Shafer
Section 7 Developmental and Behavioral Pediatrics
Martin T. Stein
Part 1 General Concepts
79 Introduction to Developmental and Behavioral Pediatrics 305(1)
Martin T. Stein
80 Fundamental Concepts of Child Development 306(4)
W. Thomas Boyce
Jack P. Shonkoff
81 Brain Development and Behavior 310(3)
Charles A. Nelson III
82 Standardized Developmental Screening and Assessment Instruments 313(5)
Martin T. Stein
Part 2 Developmental Variation to Disorder
83 Crying in Infants 318(3)
Ronald G. Ban
Takeo Fujiwara
84 Hyperactivity and Inattention 321(6)
Martin T. Stein
Michael I. Reiff
85 Learning Problems 327(4)
Michael I. Reiff
Martin T. Stein
86 Language Delay 331(4)
James S. Andrews
Heidi M. Feldman
87 Difficult Behavior 335(3)
Martin T. Stein
88 Anxiety 338(4)
Denise A. Chavira
89 Repetitive Behaviors 342(4)
Adrian D. Sandler
90 Gender Identity and Sexual Behavior 346(2)
Kenneth J. Zucker
91 Developmental Delay 348(4)
Nathan J. Blum
Part 3 Major Psychopathologic Disorders
92 Autistic Spectrum Disorders 352(4)
Michael I. Reiff
93 Affective Disorders and Suicide 356(4)
Laura Prager
Steven C. Schlozman
Michael Jellinek
94 Pediatric Condition Falsification 360(1)
Herbert Schreier
95 Childhood Schizophrenia 361(2)
Fred R. Volkmar
Part 4 Psychosocial Context of Development and Behavior
96 Families in the 21st Century: An Introduction to Families 363(1)
Laurie J. Bauman
Ruth E. K. Stein
97 Nonparental Childcare 364(2)
Nerissa S. Bauer
98 Vulnerable Child Syndrome 366(2)
Yi Hui Liu
99 Adaptation to Illness 368(2)
David J. Schonfeld
Ellen C. Perrin
100 Poverty, Homelessness, and Social Disorganization 370(2)
Barry S. Zuckerman
Megan Sandel
101 Resiliency in Children and Adolescents 372(3)
Saul Levine
Section 8 The Acutely III Infant and Child
Julio Perez Fontan
George E. Lister
Part 1 Assessment of the Acutely III Infant and Child
102 Respiratory Distress and Failure 375(8)
Julio Perez Fontan
103 Decreased Perfusion and Circulatory Shock 383(8)
George E. Lister
104 Acute Neurological Dysfunction 391(6)
Susan T. Arnold
105 The Febrile Child 397(3)
M. Douglas Baker
Jeffrey R. Avner
Part 2 Stabilization and Management of the Acutely III Infant and Child
106 Monitoring of Vital Function 400(4)
George E. Lister
107 Vascular Access 404(4)
Andreas A. Theodorou
Robert A. Berg
108 Cardiopulmonary Resuscitation 408(4)
Mary Fran Hazinski
109 Life Support Systems 412(5)
Julio Perez Fontan
110 Stabilization and Transport 417(3)
Deborah Lerner
George E. Lister
Julio Perez Fontan
111 Management of Cerebral Edema and Elevated Intracranial Pressure 420(2)
Steven G. Kernie
112 Perioperative Care 422(4)
Desmond B. Henry
113 Pain Management and Sedation 426(6)
Alan Farrow-Gillespie
114 Acute Metabolic Dysfunction 432(4)
Ralph J. DeBerardinis
Part 3 Injuries and Untoward Events
115 Acute Inflammation 436(4)
Clifford W. Bogue
116 Trauma, Burns, and Bites 440(6)
Robert P. Foglia
117 Submersion Injury 446(3)
Pamela J. Okada
M. Douglas Baker
118 Foreign-Body Aspiration 449(2)
Margaret A. Kenna
119 Apparent Life-Threatening Events and SIDS 451(4)
Michael J. Corwin
120 Toxic Ingestions and Exposures 455(15)
Sing-Yi Feng
Collin S. Goto
M. Douglas Baker
121 Heat Stress 470(2)
Michael Apkon
122 Poisonous Bites and Stings 472(7)
Dee Hodge III
Carl R. Baum
Section 9 The Chronically III Infant and Child
Julia Perez Fontan
George E Lister
Part 1 The Changing Outlook of Chronic Illness in Childhood
123 Psychological and Behavioral Responses 479(5)
Patricia J. Hicks
124 The Technology-Dependent Child 484(10)
John B. Gordon
Sarah P. Brown
Jerie Beth Karkos
Lynn A. D Andrea
Part 2 Death and Dying in Childhood
125 Caring for Children Dying from Chronic Disease 494(7)
Arthur R. Ablin
126 Hospice and Palliative Care 501(9)
Julie Hauer
Barbara L. Jones
Joanne Wolfe
127 Law, Ethics, and Caring Near the End of Life 510(3)
Angela Roddey Holder
Section 10 Transplantation
Patrick J. Healey
128 Pediatric Transplantation 513(5)
Patrick J. Healey
129 Kidney Transplantation 518(3)
Jodi M. Smith
Ruth A. McDonald
130 Liver Transplantation 521(4)
Patrick J. Healey
131 Intestinal and Multivisceral Transplant 525(3)
Simon Horslen
132 Heart Transplant 528(3)
Beth D. Kaufman
133 Hematopoietic Cell Transplantation 531(10)
Ann E. Woolfrey
Paul A. Carpenter
Jean E. Sanders
Section 11 Inherited Disorders of Metabolism
Jean-Marie Saudubray
Part 1 Inborn Errors of Metabolism
134 Principles of Inborn Errors of Metabolism 541(20)
Jean-Marie Saudubray
Joe T. R. Clarke
Part 2 Disorders of Amino Acid (AA) and Organic Acid (OA) Metabolism
135 Hyperphenylalaninemias 561(2)
Bernd Christian Schwahn
136 Disorders of Tyrosine Metabolism 563(2)
Bernd Christian Schwahn
137 Disorders of Branched Chain Amino and Organic Acid Metabolism 565(4)
Stephen I. Goodman
Jean-Marie Saudubray
138 Disorders of Sulfur-Containing Amino Acid Metabolism 569(3)
Bernd Christian Schwahn
139 Disorders of Glycine, Serine, and Proline Metabolism 572(2)
Bernd Christian Schwahn
140 Disorders of Metabolism of Lysine, Hydroxylysine, and Related Compounds 574(1)
Stephen I. Goodman
141 Disorders of Metabolism of Neurotransmitter Amino Acids 574(3)
Jaak Jaeken
142 Disorders of Creatine and Ornithine Metabolism 577(2)
Sylvia Stockler-Ipsiroglu
143 Disorders of Amino Acid Transport Across Cell Membranes 579(2)
Kirsti Nanto-Salonen
Ollie Simell
144 Other Disorders of Amino Acid Metabolism 581(1)
Jean-Marie Saudubray
145 Urea Cycle and Related Disorders 582(6)
Mendel Tuchman
Uta Lichter-Konecki
Mark L. Batshaw
Part 3 Inborn Errors of Water Soluble Vitamins
146 Introduction 588(1)
Stephen I. Goodman
147 Vitamin B12 and Folic Acid 588(3)
David Watkins
David S. Rosenblatt
148 Biotin Responsive Disorders 591(1)
Stephen I. Goodman
149 Vitamin B6 and Vitamin B1 Responsive Disorders 592(2)
Jean-Marie Saudubray
Part 4 Disorders of Fatty Acid Oxidation, Ketogenesis, and Ketolysis
150 Disorders of Fatty Acid Oxidation 594(3)
Stephen I. Goodman
151 Disorders of Ketogenesis 597(1)
Stephen I. Goodman
152 Disorders of Ketolysis 598(1)
Stephen I. Goodman
153 Disorders of Leukotriene Synthesis and Fatty Aldehyde Dehydrogenase 598(1)
Stephen I. Goodman
Part 5 Carbohydrate Metabolism
154 Disorders of Glycogen Metabolism 599(8)
Priya S. Kishnani
Yuan-Tsong Chen
155 Disorders of Galactose and Fructose Metabolism and Gluconeogenesis 607(3)
Priya S. Kishnani
Yuan-Tsong Chen
156 Disorders of Pentose Phosphate Pathway 610(1)
Priya S. Kishnani
Yuan-Tsong Chen
157 Disorders of Glucose Transporters 610(4)
Rene Santer
Part 6 Disorders of Oxidative Phosphorylation and Pyruvate Oxidation
158 Respiratory Chain Disorders 614(6)
Salvatore DiMauro
159 Disorders of Energy Metabolism 620(2)
Juan M. Pascual
Salvatore DiMauro
Part 7 Organelle-Related Disorders
160 Mucopolysaccharidosis, Glycoproteinosis, and Mucolipidosis 622(11)
James Edmond Wraith
161 Sphingolipidoses 633(4)
Joe T. R. Clarke
162 Peroxisomal Disorders 637(5)
David Valle
Gerald V. Raymond
Stephen J. Gould
163 Congenital Disorders of Glycosylation 642(3)
Jaak Jaeken
Part 8 Disorders of Lipid and Bile Acid Metabolism
164 Disorders of Cholesterol Synthesis 645(2)
Peter T. Clayton
165 Disorders of Bile Acid Synthesis 647(4)
Peter T. Clayton
166 Disorders of Lipid and Lipoprotein Metabolism 651(11)
Peter O. Kwiterovich Jr
Part 9 Disorders of Nucleic Acids, Heme Metabolism, and Metals Transport
167 Disorders of Heme Biosynthesis: The Porphyrias 662(6)
Robert J. Desnick
168 Disorders of Purine and Pyrimidine Metabolism 668(5)
Georges van den Berghe
169 Disorders of Metal Metabolism 673(4)
Jean-Marie Saudubray
Section 12 Clinical Genetics and Dysmorphology
John C. Carey
Michael J. Bamshad
Part 1 The Genetic Approach to Disorders of Children
170 Key Principles in Human Genetics 677(7)
Michael J. Bamshad
Lynn B. Jorde
171 Multifactorial Inheritance 684(3)
Lynn B. Jorde
172 Principles of Care 687(1)
Claire O. Leonard
Part 2 Chromosomal Disorders
173 Human Cytogenetics 688(3)
Sarah T. South
John C. Carey
174 Chromosome Disorders 691(6)
John C. Carey
Part 3 Birth Defects, Malformations, and Syndromes
175 Birth Defects, Malformations, and Syndromes 697(3)
John C. Carey
Michael J. Bamshad
176 Syndromes of Multiple Congenital Anomalies/Dysplasias 700(5)
John C. Carey
177 Craniofacial Disorders 705(8)
Carrie Lyn Heike
Michael L. Cunningham
178 Approach to the Child with Birth Defects 713(3)
John C. Carey
Michael J. Bamshad
179 Genetic Skeletal Disorders 716(5)
John C. Carey
Michael J. Bamshad
180 Congenital Contractures 721(1)
Michael J. Bamshad
John C. Carey
181 Connective Tissue Dysplasias 722(6)
Alan Rope
182 Neurocutaneous Disorders 728(4)
David H. Viskochil
183 Environmental Causes of Birth Defects 732(7)
Elizabeth Balken
Marsha Leen-Mitchell
Lynn P. Martinez
Julia A. Robertson
184 Disorders of Accelerated Aging 739(3)
John C. Carey
185 Genetic Evaluation of Developmental Delay/Mental Retardation 742(7)
Agatino Battaglia
John C. Carey
Section 13 Immunologic Disorders
Talal A. Chatila
186 Overview of the Immune System 749(6)
Eli M. Eisenstein
Kathleen E. Sullivan
Calvin B. Williams
187 Undue Susceptibility to Infection 755(2)
Talal A. Chatila
188 Primary Immunodeficiencies 757(8)
Talal A. Chatila
189 Complement Disorders 765(4)
Patricia C. Giclas
Ashley A. Frazer-Abel
Section 14 Allergic Disorders
Talal A. Chatila
190 Allergic Disease and Atopy 769(2)
Talal A. Chatila
191 Clinical Aspects of Allergic Diseases 771(4)
Maria Garcia-Lloret
192 Allergic Rhinitis and Conjunctivitis 775(2)
Maria Garcia-Lloret
193 Anaphylaxis, Urticaria, and Angioedema 777(3)
Marc A. Riedel
194 Food Allergy 780(2)
Maria Garcia-Lloret
195 Insect Allergy 782(1)
Maria Garcia-Lloret
196 Latex Allergy 783(1)
Marc A. Riedel
197 Adverse Reactions to Drugs 784(3)
Marc A. Riedel
Section 15 Rheumatology
Robert P. Sundel
Part 1 General Principles in Rheumatology
198 Pathogenesis of Inflammatory and Autoimmune Disorders 787(5)
Kathleen E. Sullivan
199 History and Physical Examination in Rheumatology 792(3)
Robert P. Sundel
200 Diagnostic Testing in Rheumatology 795(5)
Peter A. Nigrovic
Part 2 Specific Rheumatologic Disorders
201 Juvenile Idiopathic Arthritis 800(6)
Carol A. Wallace
David A. Cabral
Robert P. Sundel
202 Spondyloarthropathies 806(4)
David A. Cabral
Lori B. Tucker
203 Vasculitides 810(4)
Karyl S. Barron
204 Systemic Lupus Erythematosus, Overlap Connective Tissue Diseases, and Mixed Connective Tissue Disease 814(4)
Earl D. Silverman
205 Juvenile Dermatomyositis 818(5)
Lisa G. Rider
206 Scleroderma 823(3)
Francesco Zulian
Part 3 Systemic Syndromes in Rheumatology
207 Musculoskeletal Pain Syndromes 826(4)
Yukiko Kimura
208 Chronic Fatigue Syndrome 830(2)
David S. Leslie
209 Autoinflammatory Disorders 832(7)
Philip J. Hashkes
Section 16 The Musculoskeletal System
John A. Herring
210 Growth and Development 839(2)
John G. Birch
211 The Limping Child 841(1)
Lawson A. B. Copley
212 Torsional and Angular Deformities 842(3)
Karl E. Rathjen
213 Disorders of the Foot 845(6)
Charles E. Johnston
214 Disorders of the Knee 851(1)
John A. Herring
215 Developmental Dysplasia of the Hip 852(4)
David A. Podeszwa
216 Disorders of the Neck and Spine 856(6)
Daniel J. Sucato
217 Disorders of the Upper Extremity 862(3)
Marybeth Ezaki
218 Injuries 865(5)
Philip Wilson
219 Tumors 870(2)
B. Stephens Richards
220 Neuromuscular Disorders 872(2)
Lori A. Karol
221 Common Orthopedic Misses 874(3)
John A. Herring
Section 17 Infectious Diseases
Anne A. Gershon
Peter J. Hotez
Part 1 Principles of Infectious Disease
222 Bacterial Pathogenesis 877(3)
Janet R. Gilsdorf
Carl F. Marrs
223 Bacteremia, Sepsis, and Septic Shock 880(3)
Stephanie H. Stovall
Richard F. Jacobs
224 Viral Pathogenesis 883(2)
Anne Moscona
Anne A. Gershon
225 Infection Control 885(3)
Margaret C. Fisher
226 Diagnostic Approaches for Infectious Diseases 888(5)
John C. Christenson
E. Kent Korgenski
227 Acute Fever without a Focus 893(2)
Steven Black
228 Fever of Unknown Origin 895(2)
Russell W. Steele
229 Fever and Infection in the Immunocompromised Patient 897(5)
David B. Haslam
Jeffrey Scott McKinney
230 Therapy for Perinatal and Neonatal Infections 902(11)
David W. Kimberlin
Debra L. Palazzi
Richard J. Whitley
Part 2 Infections of Organ Systems
231 Bacterial Infections of the Central Nervous System 913(6)
Thomas S. Murray
Robert S. Baltimore
232 Viral Infections of the Central Nervous System 919(4)
John F. Modlin
233 Sexually Transmitted Infections 923(11)
Loris Y. Hwang
Anna-Barbara Moscicki
Mary-Ann Shafer
234 Bone, Joint, Soft Tissue Infections 934(5)
Robin B. Churchill
Blanca E. Gonzalez
235 Cardiac Infections 939(6)
Janet A. Stockheim
Stanford T. Shulman
236 Gastrointestinal Infections 945(2)
Matthew B. Laurens
Michael S. Donnenberg
237 Infections of the Liver 947(3)
M. Kyle Jensen
Grzegorz Telega
238 Urinary Tract Infections 950(6)
Keith M. Krasinski
239 Catheter-Associated Infections 956(3)
Marc Foca
Part 3 Infections of the Respiratory System
240 Community-Acquired and Bacterial Pneumonia in Children 959(2)
Stephen I. Pelton
241 Viral Respiratory Infections Including Influenza 961(9)
J. Robert Honegger
Michael T. Brady
242 Fungal Respiratory Infections 970(3)
Hana Hakim
Aditya H. Gaur
243 Infections of the Ear 973(7)
Jerome O. Klein
Part 4 Treatment and Prevention of Infectious Diseases
244 Immunizations 980(12)
Kristina A. Bryant
245 Antiviral Therapy 992(4)
David K. Hong
Charles G. Prober
246 Antibacterial Therapy 996(15)
David K. Hong
Charles G. Prober
247 Antifungal Therapy 1011(5)
Patricia M. Flynn
Part 5 Bacterial Infections
248 Actinomycosis 1016(2)
Nahed Abdel-Haq
Ashir Kumar
249 Anaerobic Infections 1018(3)
Ayesha Mirza
Mobeen H. Rathore
250 Clostridial Infections 1021(2)
Jose Zayas
Mobeen H. Rathore
251 Anthrax (Bacillus anthracis) 1023(1)
Denise Bratcher
252 Arcanobacterium 1024(1)
Dennis L. Murray
253 Bacillus cereus 1024(1)
Denise Bratcher
254 Brucellosis 1025(1)
Ziad M. Shehab
255 Burkholderia and Pseudomonas 1026(1)
Jane L. Burns
256 Campylobacter 1027(1)
Guillermo M. Ruiz-Palacios
257 Cat Scratch Disease (Bartonella henselae) 1028(2)
Moshe Ephros
Michael Giladi
258 Chancroid (Hemophilus ducreyi) 1030(1)
Mary Allen Staat
259 Chlamydia 1031(3)
Navjyot K. Vidwan
Mary Allen Staat
260 Cholera 1034(2)
Chokechai Rongkavilit
Ashir Kumar
261 Diphtheria 1036(2)
Gary D. Overturf
262 Enterococcus 1038(1)
Dwight A. Powell
263 Haemophilus influenzae 1039(4)
Mark R. Schleiss
Arnold L. Smith
264 Legionella Pneumonia 1043(1)
Lorry G. Rubin
265 Leptospirosis 1044(1)
Anne A. Gershon
Michael Katz
266 Listeriosis 1045(1)
Ziad M. Shehab
267 Lyme Disease 1046(2)
Michael A. Gerber
268 Moraxella catarrhalis 1048(1)
Basim I. Asmar
269 Tuberculosis (Mycobacteria tuberculosis) 1049(9)
Jeffrey R. Starke
270 Nontuberculous Mycobacterial Infections 1058(3)
Jeffrey R. Starke
271 Leprosy 1061(3)
Wayne M. Meyers
Francoise Portaels
Douglas S. Walsh
272 Buruli Ulcer (Mycobacterium ulcerans Infection) 1064(2)
Wayne M. Meyers
Francoise Portaels
Douglas S. Walsh
273 Mycoplasma Infections 1066(2)
Julia A. McMillan
274 Neisseria gonorrhoeae 1068(2)
Mary Allen Staat
275 Neisseria meningitidis 1070(3)
Michele Estabrook
276 Nocardiosis 1073(1)
Nahed Abdel-Haq
Ashir Kumar
277 Pasteurella multocida 1074(1)
Morven S. Edwards
278 Pertussis 1075(2)
Beverly L. Connelly
279 Plague 1077(1)
Gary D. Overturf
280 Pneumococcal Infections 1078(2)
Sandra R. Arnold
P. Joan Chesney
281 Rat-Bite Fever 1080(1)
Lorry G. Rubin
282 Relapsing Fever 1081(176)
Dennis L. Murray
358 Disorders of the Epidermis 1257(6)
Kristen B. Holland
359 Disorders of the Dermis and Subcutaneous Tissue 1263(1)
Anita N. Haggstrom
360 Genetic Disorders of the Skin 1264(7)
Brook E. Tlougan
Amy S. Paller
361 Melanocytic Lesions and Disorders of Pigmentation 1271(6)
Julie V. Schaffer
Seth J. Orlow
362 Immunologic Diseases 1277(5)
Julie Prendiville
363 Neoplastic and Proliferative Disorders 1282(1)
Victoria R. Barrio
Lawrence F. Eichenfield
364 Vascular Tumors and Malformations 1283(4)
Ilona J. Frieden
Sheilagh M. Maguiness
365 Acne and Other Disorders of the Pilosebaceous Unit 1287(3)
Sara W. Dill
Bari B. Cunningham
366 Disorders of Nails 1290(1)
Liborka Kos
367 Skin Infections and Exanthems 1291(10)
Jane S. Bellet
Anthony J. Mancini
368 Infestations 1301(4)
Denise W. Metry
Section 19 Disorders of the Ear, Nose, and Throat
Joseph Kerschner
369 The Ear 1305(12)
John H. Greinwald Jr.
Margaret A. Kenna
Blake C. Papsin
370 Nose and Sinus 1317(7)
Ellen S. Deutsch
Cecille G. Sulman
371 The Pharynx and Upper Airway 1324(11)
Marshall E. Smith
372 The Head, Face, and Neck 1335(3)
Craig S. Derkay
Michael J. Cunningham
373 Head and Neck Masses 1338(5)
David E. Tunkel
Jonathan A. Perkins
Section 20 Disorders of the Oral Cavity
Howard L. Needleman
Stephen Shusterman
374 Dental Caries 1343(3)
Man Wai Ng
Isabelle I. Chase
375 Dental Emergency Care 1346(4)
Howard L. Needleman
Brian Grove
376 Dental Occlusion and Its Management 1350(4)
Richard Bruun
Sivabalan Vasudavan
377 Periodontal and Gingival Health and Diseases 1354(2)
Nadeem Y. Karimbux
David M. Kim
378 Oral Pathology 1356(5)
Andrew L. Sonis
Brian Grove
379 Temporomandibular Joint Disorders 1361(1)
Bonnie L. Padwa
380 Behavioral Treatment Options in Pediatric Dentistry 1362(3)
Stephen Shusterman
Linda P. Nelson
Section 21 Disorders of the Gastrointestinal System
Colin D. Rudolph
Part 1 Presenting Signs and Symptoms
381 Normal Structure and Function of the Gastrointestinal Tract 1365(7)
Alan N. Mayer
382 Approach to the Child with Acute, Chronic, or Cyclic Vomiting 1372(3)
B U. K. Li
383 Acute Abdominal Pain 1375(2)
J. Craig Egan
John J. Aiken
Colin D. Rudolph
384 Chronic Abdominal Pain 1377(4)
Adrian Miranda
385 Diarrhea 1381(5)
Ricardo A. Caicedo
Ivor D. Hill
386 Constipation and Fecal Incontinence 1386(3)
Manu R. Sood
387 Upper and Lower Gastrointestinal Bleeding 1389(2)
Richard J. Noel
388 Abdominal Masses 1391(3)
John C. Densmore
Keith T. Oldham
389 Gastrointestinal Obstruction 1394(2)
Pradeep Nazarey
Thomas T. Sato
390 Protein-Losing Enteropathy 1396(2)
Richard J. Noel
391 Gastrointestinal Disorders Associated with Immunodeficiency 1398(2)
Richard J. Noel
Part 2 Esophageal Disorders
392 Anatomic Disorders of the Esophagus 1400(3)
Dave R. Lai
393 Disorders of Esophageal Motility 1403(2)
Neelesh A. Tipnis
394 Gastroesophageal Reflux and Other Causes of Esophageal Inflammation 1405(7)
Colin D. Rudolph
395 Other Esophageal Disorders 1412(3)
Tonya Adamiak
Colin D. Rudolph
Part 3 Congenital and Anatomic Disorders of the Stomach and Intestine
396 Abdominal Wall Defects 1415(2)
Danielle B. Peterson
Marjorie J. Area
397 Malrotation and Volvulus 1417(3)
John J. Aiken
398 Infantile Hypertrophic Pyloric Stenosis 1420(1)
Rachel Adams Greenup
Casey M. Calkins
399 Congenital Atresias, Stenosis, and Webs 1421(1)
Andrea Winthrop
Jill Whitehouse
400 Microgastria and Gastric Perforation 1422(1)
Andrea Winthrop
Jill Whitehouse
401 Duplications and Cysts 1423(2)
Denise B. Klinkner
David M. Gourlay
402 Omphalo-Mesenteric Duct Remnants 1425(2)
Denise B. Klinkner
David M. Gourlay
403 Meconium Diseases of Infancy and Distal Intestinal Obstruction Syndrome 1427(1)
Pradeep Nazarey
Thomas T. Sato
404 Intussusception 1428(1)
John C. Densmore
Dave R. Lal
405 Inguinal and Other Hernias 1429(3)
John J. Aiken
406 Superior Mesenteric Artery Syndrome 1432(1)
Vincent P. Biank
407 Motor Disorders of the Stomach, Small Bowel, and Colon 1433(5)
Manu R. Sood
Casey M. Calkins
Part 4 Disorders of Digestion and Absorption
408 Disorders of Digestion and Absorption 1438(16)
Ivor D. Hill
Ricardo A. Caicedo
Part 5 Disorders of the Stomach and Intestine
409 Inflammatory Disorders of the Stomach 1454(6)
Ranjan Dohil
Eric Hassall
410 Inflammatory Bowel Disease 1460(8)
Michael C. Stephens
Subra Kugathasan
Thomas T. Sato
411 Allergic and Eosinophilic Gastroenteropathies 1468(3)
B U. K. Li
412 Vascular, Systemic, and Other Disorders Affecting the Gastrointestinal Tract 1471(2)
Grzegorz Telega
Vincent F. Blank
B U. K. Li
413 Acute Appendicitis, Typhlitis, and Chronic Appendicitis 1473(2)
J. Craig Egan
John J. Aiken
Grzegorz Telega
B U. K. Li
414 Polyps and Tumors of the Gastrointestinal Tract 1475(5)
Steven H. Erdman
Edward J. Hoffenberg
415 Congenital Anomalies of the Anorectum 1480(2)
Casey M. Calkins
Manu R. Sood
416 Other Anorectal Disorders 1482(3)
Judith M. Sondheimer
Part 6 The Exocrine Pancreas
417 Disorders of the Exocrine Pancreas 1485(6)
Steven L. Werlin
Section 22 Disorders of the Liver and Biliary Tract
Saul Karpen
418 Structure and Function of the Liver 1491(4)
Jonathan E. Teitelbaum
419 Evaluation of the Infant and Child with Liver Disease 1495(6)
Robert H. Squires Jr
420 Autoimmune Disorders of the Liver 1501(2)
Nada Yazigi
421 Metabolic and Genetic Disorders of the Liver 1503(9)
Frederick J. Suchy
422 Drug, Toxin, and TPN Liver Disease 1512(3)
Christopher D. Jolley
Regino P. Gonzalez-Peralta
Beth A. Carter
423 The Liver in Systemic Disease 1515(2)
Maureen M. Jonas
424 Acute Liver Failure 1517(3)
Vicky Lee Ng
425 End-Stage Liver Disease 1520(4)
Vicky Lee Ng
426 Other Disorders of the Liver 1524(3)
Stephanie Abrams
Gregorz Telega
427 The Biliary Tract 1527(8)
Colin D. Rudolph
Gregorz Telega
Vincent F. Blank
Douglas S. Fishman
Section 23 Disorders of the Blood
George R. Buchanan
Part 1 Principles of Blood Disorders
428 Approach to Suspected Hematologic Disorders 1535(3)
George R. Buchanan
429 Hematopoeisis 1538(4)
Charles T. Quinn
Part 2 Disorders of Red Blood Cells and Anemia
430 Anemia 1542(4)
Matthew M. Heeney
431 Iron Deficiency 1546(3)
Matthew M. Heeney
432 Anemia Due to Diminished Red Blood Cell Production 1549(3)
Zora R. Rogers
433 Hemolytic Anemia 1552(4)
Amber Mayfield Yates
Russell E. Ware
434 Hemoglobinopathies 1556(11)
Charles T. Quinn
Part 3 Disorders of Coagulation and Platelets
435 Normal and Abnormal Hemostasis 1567(3)
Janna M. Journeycake
Janet Yang
Anthony K. C. Chan
436 Inherited Bleeding Disorders 1570(4)
Amy L. Dunn
Shannon L. Meeks
Thomas C. Abshire
437 Acquired Coagulation Disorders 1574(3)
Guy Young
438 Diagnosis and Management of Thrombosis 1577(4)
Janna M. Journeycake
Anthony K. C. Chan
439 Disorders of Platelets 1581(6)
Cindy E. Neunert
Donald L. Yee
Part 4 Disorders of the Spleen and Lymph Nodes
440 The Spleen and Lymph Nodes 1587(3)
Shelley E. Crary
Part 5 Disorders of White Blood Cells
441 Disorders of Granulocytes 1590(7)
R. Alexander Blackwood
Lawrence A. Boxer
Part 6 Principles of Transfusion
442 Transfusion Medicine 1597(6)
Cassandra D. Josephson
Section 24 Neoplastic Disorders
Robert J. Arced
Part 1 Principles of Oncology
443 Cancer Genetics and Biology 1603(4)
David Malkin
444 Epidemiology of Childhood Cancer 1607(1)
Louise Parker
445 Chemotherapy and Radiation Therapy 1608(4)
Peter C. Adamson
Larry E. Kun
446 Clinical Trials in Pediatric Oncology 1612(2)
Malcolm A. Smith
Gregory H. Reaman
447 Neonatal Oncology 1614(2)
Sheila Weitzman
Yaron Finkelstein
Robert J. Arceci
448 Cancer Survivorship and Recommendations for Follow-Up 1616(4)
Smita Bhatia
Anna T. Meadows
Part 2 Hematologic Malignancies
449 Acute Lymphoblastic Leukemia 1620(5)
James B. Nachman
450 Myeloid Malignancies 1625(5)
Soheil Meshinchi
Robert J. Arceci
Howard J. Weinstein
451 Non-Hodgkin Lymphoma 1630(2)
Mitchell S. Cairo
Thomas G. Gross
452 Hodgkin Lymphoma 1632(5)
Melissa M. Hudson
Tanya M. Trippett
Part 3 Solid Tumors
453 Osteosarcoma 1637(2)
Richard Gorlick
Paul A. Meyers
454 Ewing Sarcoma and Primitive Neuroectodermal Tumor 1639(2)
Crystal L. Mackall
Jeffrey A. Toretsky
455 Rhabdomyosarcoma 1641(3)
Douglas S. Hawkins
Frederic G. Ban
456 Renal Tumors 1644(3)
Elizabeth Mullen
457 Neuroblastoma 1647(4)
Michael D. Hogarty
Garrett M. Brodeur
458 Malignant Liver Tumors 1651(3)
Gail E. Tomlinson
Howard M. Katzenstein
459 Germ Cell Tumors 1654(2)
Thomas A. Olson
460 Brain Tumors and Spinal Tumors 1656(5)
Kenneth J. Cohen
Ian F. Pollack
461 Retinoblastoma 1661(1)
Rima F. Jubran
Anna T. Meadows
462 Vascular Neoplasms 1662(2)
Denise M. Adams
Michael E. Kelly
Part 4 Mononuclear Phagocytic System Disorders
463 Histiocytic Disorders 1664(5)
R. Maarten Egeler
Robert J. Arceci
Jan-Inge Henter
Section 25 Disorders of the Kidney and Urinary Tract
Norman D. Rosenblum
Part 1 Principles of Nephrology
464 Renal Morphogenesis 1669(2)
Sunder Sims-Lucas
Carlton M. Bates
465 Development of Renal Function 1671(6)
Tino D. Piscione
466 Fluid, Electrolyte, and Acid-Base Disorders 1677(9)
Manjula Gowrishankar
467 Diagnostic Approach to Renal Disease 1686(5)
John W. Foreman
Part 2 Abnormalities of the Kidney and Urinary Tract
468 Kidney or Urinary Tract Disorders 1691(6)
John W. Foreman
469 Renal Malformations 1697(3)
Norman D. Rosenblum
470 Cystic Diseases of the Kidney 1700(6)
Friedhelm Hildebrandt
471 Acute Renal Failure 1706(4)
Prasad Devarajan
472 Glomerular Diseases 1710(19)
Allison A. Eddy
473 Hereditary Glomerulopathies 1729(3)
Clifford E. Kashtan
474 Renal Tubular Disorders 1732(6)
Michel Baum
475 Urinary Tract Stone Diseases 1738(3)
Valerie Langlois
476 Urologie Abnormalities of the Genitourinary Tract 1741(8)
Luis H. P. Braga
Darius J. Bagli
Part 3 Chronic Kidney Disease
477 Chronic Kidney Disease 1749(6)
Denis F. Geary
478 Chronic Dialysis 1755(2)
Stuart L. Goldstein
479 Systemic Hypertension 1757(12)
Craig W. Belsha
Joseph T. Flynn
Section 26 Disorders of the Cardiovascular System
Julien I. E. Hoffman
David F. Teitel
Part 1 Principles of Cardiology
480 Development of the Cardiovascular System 1769(6)
Deepak Srivastava
481 Genetics of Heart Disease 1775(7)
Kathleen M. Ruppel
Part 2 Approach to the Patient with Cardiovascular Disease
482 Fetal Cardiology 1782(7)
Lisa K. Hornberger
Jean Trines
483 Neonate and Infant with Cardiovascular Disease 1789(15)
David F. Teitel
484 Congenital Heart Disease 1804(31)
Julien I. E. Hoffman
485 Arrhythmias 1835(13)
George F. Van Hare
486 Child and Adolescent with Cardiovascular Disease 1848(7)
Howard P. Gutgesell
George M. McDaniel
Part 3 Acquired Cardiovascular Disease
487 Cardiac Tumors 1855(1)
Julien I. E. Hoffman
488 Kawasaki Disease 1855(3)
Mary Beth Son
Jane W. Newburger
489 Diseases of Myocardium 1858(3)
Jeffrey A. Towbin
490 Infective Endocarditis 1861(2)
Jane W. Newburger
491 Pericardial Diseases 1863(4)
Julien I. E. Hoffman
492 Pulmonary Hypertension 1867(2)
Julien I. E. Hoffman
Part 4 Diagnostic Tools in Heart Disease
493 Electrocardiography 1869(4)
George F. Van Hare
494 Radiologic Imaging 1873(6)
Alison Knauth Meadows
Michael W. Dae
495 Echocardiography 1879(4)
Theresa A. Tacy
496 Cardiac Catherization 1883(4)
Phillip Moore
Part 5 Management of Patients with Cardiovascular Disease
497 Heart Failure 1887(6)
Robert E. Shaddy
Chitra Ravishankar
498 The Patient with Single Ventricle 1893(4)
Jacqueline Kreutzer
499 Interventional Cardiology 1897(6)
Phillip Moore
500 Health Care Management for the Child with Cardiovascular Disease 1903(3)
Mark Cocalis
501 Sports Screening for Cardiovascular Risk 1906(3)
Mark Cocalis
Julien I. E. Hoffman
Section 27 Disorders of the Respiratory System
Jay K. Kolls
Part 1 Principles of Pulmonology
502 Lung Growth in Infancy and Childhood 1909(4)
Richard L. Auten
503 Physiologic Basis of Pulmonary Function 1913(4)
Daniel J. Weiner
504 Global Burden of Respiratory Infections and Mucosal Immunology of the Respiratory Tract 1917(3)
Jay K. Kolls
Joseph P. Mizgerd
505 Clinical Presentation of Respiratory Illness 1920(4)
Hans Pasterkamp
506 Tools for Diagnosis and Management of Respiratory Disease 1924(4)
Beverley Newman
Geoffrey Kurland
Part 2 Disorders of the Respiratory System
507 Congenital Disorders of the Lower Airways and Mediastinum 1928(5)
Andrew Bush
508 Disorders of Respiratory Control and Sleep-Disordered Breathing 1933(9)
David Gozal
Leila Kheirandish-Gozal
509 Sleep Disorders 1942(7)
Hemant Sawnani
Narong Simakajornboon
510 Disorders Causing Airway Obstruction 1949(9)
Shean J. Aujla
Jonathan E. Spahr
511 Aspiration Syndromes 1958(4)
Cori L. Daines
512 Asthma 1962(12)
Gurjit K. Khurana Hershey
513 Bronchopulmonary Dysplasia 1974(3)
Timothy D. Murphy
514 Cystic Fibrosis 1977(9)
David M. Orenstein
515 Interstitial Lung Disease 1986(3)
Jennifer A. Rama
Leland L. Fan
516 Alpha-1 Antitrypsin Deficiency Lung Disease 1989(1)
Terence R. Flotte
Christian Mueller
517 Pulmonary Vasculitis Syndromes 1990(3)
Paul Rosen
518 Pulmonary Alveolar Proteinosis 1993(3)
Bruce C. Trapnell
Lisa R. Young
519 Chest Wall and Respiratory Muscle Disorders 1996(5)
Jonathan D. Finder
Section 28 Disorders of the Endocrine System
Allen W. Root
520 Mechanisms of Hormone Action 2001(8)
Adda Grimberg
Linda A. DiMeglio
521 Disorders of the Anterior Pituitary Gland 2009(3)
Edward O. Reiter
522 Growth and Growth Impairment 2012(5)
Edward O. Reiter
523 Endocrine Abnormalities Causing Growth Impairment 2017(6)
Edward O. Reiter
524 Tall Stature 2023(1)
Edward O. Reiter
525 Primary Disturbances in Water Homeostasis 2024(4)
Abhinash Srivatsa
Joseph A. Majzoub
526 The Thyroid 2028(3)
Delbert A. Fisher
527 Hypothyroidism in the Infant 2031(6)
Delbert A. Fisher
528 Acquired Hypothyroidism 2037(2)
Delbert A. Fisher
529 Hyperthyroidism 2039(2)
Delbert A. Fisher
530 Other Disorders of the Thyroid 2041(2)
Delbert A. Fisher
531 The Adrenal Cortex 2043(3)
Walter L. Miller
532 Evaluation of Adrenal Function 2046(2)
Walter L. Miller
533 Genetic Lesions in Steroidogenesis 2048(4)
Walter L. Miller
534 Adrenal Insufficiency 2052(3)
Walter L. Miller
535 Adrenal Excess 2055(2)
Walter L. Miller
536 Glucocorticoid Therapy and Withdrawal 2057(1)
Walter L. Miller
537 Endocrine Neoplasia Syndromes 2058(4)
Steven D. Chernausek
Constantine A. Stratakis
538 Normal Human Sex Differentiation 2062(1)
Melvin M. Grumbach
539 Disorders of Sexual Development (DSD) 2063(11)
Melvin M. Grumbach
540 Normal Pubertal Development 2074(3)
Dennis M. Styne
Leonna Cuttler
541 Abnormal Pubertal Development 2077(9)
Dennis M. Styne
Leonna Cuttler
542 Calcium, Phosphorus, and Magnesium Metabolism 2086(11)
Allen W. Root
543 Disorders of Bone Formation 2097(7)
Allen W. Root
544 Diabetes Mellitus 2104(21)
Arlan L. Rosenbloom
545 Endocrine Causes of Hypoglycemia 2125(6)
Andrea Kelly
Charles A. Stanley
Section 29 Disorders of the Nervous System
Scott L. Pomeroy
Blaise F. D. Bourgeois
Basil T. Darras
Edward M. Kaye
Part 1 Principles of Neurology
546 Introduction to Neurology 2131(2)
Mustafa Sahin
547 Clinical Approach to Neurologic Disease 2133(16)
Maitreyi Mazumdar
Part 2 Abnormal Development of the Nervous System
548 Cranial Developmental Abnormalities 2149(5)
Omar Khwaja
549 Disturbances of the Neural Tube and Spine Closure 2154(2)
Omar Khwaja
550 Macrocephaly and Microcephaly 2156(2)
Nicole J. Ullrich
Part 3 Acute Deterioration of Neurologic Function
551 Trauma to the Nervous System 2158(7)
Magdi M. Sobeih
552 Stroke and Cerebrovascular Disease 2165(9)
Michael J. Rivkin
553 Hydrocephalus and Pseudotumor Cerebri 2174(4)
Nicole J. Ullrich
554 Cerebral Palsy and Static Encephalopathies 2178(4)
Robert S. Rust
David K. Urion
555 Infections of the Central Nervous System 2182(6)
Kiran P. Maski
Nicole J. Ullrich
556 Immune- and Inflammatory-Mediated Central Nervous System Syndromes 2188(10)
Mark P. Gorman
Part 4 Epilepsy
557 Epidemiology of Epilepsy, Seizure Classification, Epilepsy Syndromes 2198(4)
Mark H. Libenson
Ann M. Bergin
558 Etiologies of Epilepsies 2202(2)
Annapurna Poduri
559 Febrile Seizures 2204(2)
Masanori Takeoka
560 Evaluation of New Onset Seizures 2206(1)
Alexander Rotenberg
561 Status Epilepticus 2206(2)
Alexander Rotenberg
562 Epilepsy Treatment: Antiepileptic Drug Therapy 2208(5)
Blaise F. D. Bourgeois
563 Epilepsy Treatment: Ketogenic Diet and Neurostimulation 2213(1)
Ann M. Bergin
564 Epilepsy Treatment: Surgery 2214(2)
Dean P. Sarco
Part 5 Paroxysmal Disorders
565 Migraine and Headache Disorders 2216(3)
Alyssa Ann LeBel
Anna Minster
566 Movement Disorders, Tics, and Tourette Syndrome 2219(4)
Diana Apetauerova
567 Other Paroxysmal Disorders 2223(1)
Sanjeev V. Kothare
Part 6 Disorders of Strength, Tone, and Sensation
568 General Evaluation of Strength, Tone, and Sensation 2224(2)
Peter B. Kang
Basil T. Darras
569 The Hypotonic Infant 2226(2)
Basil T. Darras
570 Peripheral Nerve Disorders and Anterior Horn Cell Diseases 2228(7)
Peter B. Kang
571 Diseases of the Neuromuscular Junction 2235(6)
H. Royden Jones Jr
572 Myopathies 2241(7)
Basil T. Darras
Part 7 Developmental Delay and Regression
573 Neurologic Aspects of Disorders of Metal Metabolism 2248(2)
Cecilia Mellado
Mustafa Sahin
574 Lysosomal Storage Disorders 2250(6)
Irina A. Anselm
575 Rett Syndrome (MECP2-Related Disorders) 2256(1)
Cecilia Mellado
Mustafa Sahin
576 Leukoencephalopathies 2257(8)
Mark P. Gorman
577 Neurotransmitter Disorders 2265(4)
Erika Fulhvood Augustine
Annapurna Poduri
578 Phakomatoses 2269(4)
Mustafa Sahin
Section 30 Disorders of the Eyes
Alex V. Levin
Part 1 General Principles
579 Anatomy and Physiology of the Eye and Ocular System 2273(2)
Monte A. Del Monte
580 Office Evaluation of the Eyes 2275(4)
Gregg T. Lueder
581 Special Tests of the Eyes 2279(3)
Daniel J. Karr
Alex V. Levin
582 International Pediatric Ophthalmology 2282(2)
Sherwin J. Isenberg
Leonard Apt
Part 2 Disorders of the Eye
583 Eye Emergencies and Trauma 2284(5)
Daniel J. Karr
Alex V. Levin
584 Visual Impairment in Childhood 2289(2)
David S. Walton
585 Amblyopia 2291(2)
Anthony G. Quinn
Alex V. Levin
586 Strabismus 2293(5)
Robert W. Enzenauer
Mary Ellen Hoehn
Monte A. Del Monte
587 The Eye in Child Abuse 2298(2)
Alex V. Levin
588 Red Eye 2300(4)
Anthony G. Quinn
589 Lid and Lacrimal System Disorders 2304(4)
Gregg T. Lueder
590 Anterior Segment Disorders 2308(5)
David S. Walton
591 Retinopathy of Prematurity 2313(3)
Earl A. Palmer
Irene Hsu-Dresden
592 Genetic Eye Diseases 2316(10)
J. Bronwyn Bateman
John Roarty
Christina L. Butera
Alex V. Levin
593 Optic Nerve Disorders 2326(5)
John Roarty
Index 2331
Rudolph's pediatrics /
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