Preface to the fourth edition p. x
Preface to the third edition p. xi
Preface to the second edition p. xii
Preface to the first edition p. xiii
Introduction p. 1
Viruses are Distinct from Living Organisms p. 2
The History of Virology p. 3
Living Host Systems p. 5
Cell Culture Methods p. 7
Serological/Immunological Methods p. 9
Ultrastructural Studies p. 12
'Molecular Biology' p. 18
Further Reading p. 24
Particles p. 25
The Function and Formation of Virus Particles p. 25
Capsid Symmetry and Virus Architecture p. 28
Enveloped Viruses p. 39
Complex Virus Structures p. 42
Protein-Nucleic Acid Interactions and Genome Packaging p. 49
Virus Receptors: Recognition and Binding p. 53
Other Interactions of the Virus Capsid with the Host Cell p. 53
Summary p. 54
Further Reading p. 54
Genomes p. 56
The Structure and Complexity of Virus Genomes p. 56
Molecular Genetics p. 59
Virus Genetics p. 62
Virus Mutants p. 64
Suppression p. 67
Genetic Interactions between Viruses p. 68
Nongenetic Interactions between Viruses p. 71
'Large' DNA Genomes p. 73
'Small' DNA Genomes p. 75
Positive-Strand RNA Viruses p. 78
Negative-Strand RNA Viruses p. 82
Segmented and Multipartite Virus Genomes p. 84
Reverse Transcription and Transposition p. 87
Evolution and Epidemiology p. 98
Summary p. 101
Further Reading p. 101
Replication p. 102
Overview of Virus Replication p. 102
Investigation of Virus Replication p. 104
The Replication Cycle p. 108
Summary p. 129
Further Reading p. 129
Expression p. 131
Expression of Genetic Information p. 131
Control of Prokaryote Gene Expression p. 132
Control of Expression in Bacteriophage [lambda] p. 133
Control of Eukaryote Gene Expression p. 138
Transcriptional Control of Expression p. 150
Posttranscriptional Control of Expression p. 155
Summary p. 163
Further Reading p. 164
Infection p. 165
Virus Infections of Plants p. 166
Immune Responses to Virus Infections in Animals p. 169
Viruses and Apoptosis p. 174
Interferons p. 177
Evasion of Immune Responses by Viruses p. 181
Virus-Host Interactions p. 183
The Course of Virus Infections p. 192
Virus Vectors and Gene Therapy p. 199
Chemotherapy of Virus Infections p. 200
Summary p. 206
Further Reading p. 206
Pathogenesis p. 208
Mechanisms of Cellular Injury p. 210
Viruses and Immunodeficiency p. 212
Virus-Related Diseases p. 221
Bacteriophages and Human Disease p. 224
Cell Transformation by Viruses p. 225
Viruses and Cancer p. 236
New and Emergent Viruses p. 240
Zoonoses p. 246
Bioterrorism p. 247
Summary p. 248
Further Reading p. 248
Subviral Agents: Genomes without Viruses, Viruses without Genomes p. 249
Satellites and Viroids p. 249
Prions p. 253
Summary p. 267
Further Reading p. 267
Glossary and Abbreviations p. 269
Classification of Subcellular Infectious Agents p. 281
The History of Virology p. 294
Index p. 300